Tofa 500 mg (Tablet)
Unit Price: ৳ 8.02 (50's pack: ৳ 401.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Indications
- Relief of signs and symptoms of rheumatoid arthritis
- Relief of signs and symptoms of osteoarthritis
- Relief of signs and symptoms of ankylosing spondylitis
- Relief of signs and symptoms of juvenile arthritis
- Relief of signs and symptoms of tendonitis
- Relief of signs and symptoms of bursitis
- Relief of signs and symptoms of acute gout
- Management of primary dysmenorrhea & pain
Pharmacology
- Clinical effects by blocking COX-1 and COX-2 enzymes
- Decreased prostaglandin synthesis
- Unique functional differences of COX-1 and COX-2 enzymes
Dosage & Administration
- Should be taken with water
- Adult dosage for various conditions
- Children dosage for juvenile rheumatoid arthritis
- Dosage for different weight categories in children
- Application frequency for gel
- Not recommended for use in children
Interaction
- ACE inhibitors diminish antihypertensive effect
- Antacids & Sucralfate delay the absorption
- Aspirin increases adverse effects
- Diuretics reduce natriuretic effect
- Methotrexate enhances toxicity
- Warfarin increases risk of GI bleeding
- Selective Serotonin Reuptake Inhibitors increase risk of GI bleeding
Contraindications
- Known hypersensitivity to Naproxen
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal side effects
- Central Nervous System side effects
- Dermatological side effects
- Cardiovascular side effects
- Other reported side effects
Pregnancy & Lactation
- Adverse effects on the fetus
- Delay in parturition in animals
- Association with premature closure of ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen
- Excretion in small amounts in breast milk
- Balancing benefits to the mother against possible risks to the fetus
- Considered by some authorities to be too small to be harmful to a breast-fed infant
- Recommendation to avoid breastfeeding during therapy
Precautions & Warnings
- Renal effects
- Reports of acute interstitial nephritis, hematuria, proteinuria, and occasionally nephrotic syndrome
- Caution in patients with impaired renal function
- Monitoring of serum creatinine and/or creatinine clearance
- Caution in patients with creatinine clearance of less than 20ml/min
- Hepatic effects
- Reports of moderate to severe jaundice
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children