Xenapro 500 mg (Tablet)

Unit Price: ৳ 8.03 (5 x 6: ৳ 240.90)

Strip Price: ৳ 48.18

Medicine Details

Category	Details
Generic	Naproxen sodium
Company	Renata limited

Naproxen is indicated for the relief of signs and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis, acute gout, and primary dysmenorrhea & pain. It exerts its clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. The dosage and administration vary for different conditions and age groups. It interacts with ACE inhibitors, antacids & sucralfate, aspirin, diuretics, methotrexate, warfarin, and selective serotonin reuptake inhibitors (SSRI). It is contraindicated in patients with known hypersensitivity to Naproxen and in the setting of coronary artery bypass graft (CABG) surgery. Common side effects include gastrointestinal discomfort, central nervous system effects, dermatological effects, cardiovascular effects, visual and hearing disturbances. Use during pregnancy and lactation requires careful consideration of benefits and risks. Precautions should be taken for renal and hepatic effects. It belongs to the therapeutic class of drugs for osteoarthritis, rheumatoid arthritis, and non-steroidal anti-inflammatory drugs (NSAIDs). It should be stored below 30°C, protected from light and moisture, and kept out of the reach of children.

Blocks COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis
COX-2 mediates the antipyretic, analgesic, and anti-inflammatory properties offered by Naproxen
COX-1 enzyme is linked to undesired adverse effects such as gastrointestinal upset and renal toxicities

Take with water, preferably after meals
Dosage varies for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, dysmenorrhoea, juvenile rheumatoid arthritis, analgesia and acute musculoskeletal disorders

Diminishes the antihypertensive effect of ACE inhibitors
Delays the absorption of Xenapro when taken with antacids & sucralfate
Increases adverse effects when taken with aspirin
Reduces the natriuretic effect of diuretics
Enhances the toxicity of Methotrexate
Increases the risk of GI bleeding when taken with warfarin or selective serotonin reuptake inhibitors (SSRI)

Known hypersensitivity to Naproxen
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery

Gastrointestinal discomfort: heartburn, abdominal pain, nausea, diarrhea, dyspepsia
Central nervous system effects: headache, vertigo, drowsiness
Dermatological effects: pruritus, purpura
Cardiovascular effects: edema, palpitation
Visual and hearing disturbances

May have adverse effects on the fetus
Causes a delay in parturition in animals
Associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen
Excreted in small amounts in breast milk
Use in the first and third trimesters requires careful balancing of benefits to the mother against possible risks to the fetus
Some authorities recommend avoiding breastfeeding during Naproxen therapy

Long-term administration may result in renal papillary necrosis and abnormal renal pathology
Reports of acute interstitial nephritis, hematuria, proteinuria and occasionally nephrotic syndrome
Caution in patients with significantly impaired renal function
Monitoring of serum creatinine and/or creatinine clearance is advised
Reports of moderate to severe jaundice attributed to Xenapro