Anaflex Max 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 17.00 (5 x 10: ৳ 850.00)
Strip Price: ৳ 170.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Aci limited
Also available as
Anaflex max 500 mg tablet

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers

Pharmacology

  • Consists of immediate release esomeprazole magnesium layer
  • Enteric-coated naproxen core
  • Naproxen is a NSAID with analgesic and antipyretic properties
  • Inhibits prostaglandin synthesis
  • Esomeprazole is a proton pump inhibitor
  • Suppresses gastric acid secretion

Dosage

  • Use lowest effective dose
  • Adult dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole twice daily
  • Adolescent dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole for weight >50 kg, 375 mg naproxen/20 mg esomeprazole for weight 38-50 kg

Administration

  • Tablet to be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
  • Concomitant use with warfarin may increase risk of bleeding
  • Inhibits absorption of drugs where gastric pH is important determinant of bioavailability
  • Administration with high-fat food prolongs tmax and decreases Cmax

Contraindications

  • Known hypersensitivity to any component of the tablet
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Increased risk of arterial thrombotic events at high doses
  • Gastrointestinal side effects such as peptic ulcers, perforation, GI bleeding, nausea, vomiting, diarrhea, flatulence, constipation, etc.

Pregnancy & Lactation

  • Contraindicated during third trimester of pregnancy
  • Not recommended during breastfeeding
  • Use may impair female fertility

Precautions & Warnings

  • Avoid concomitant use with NSAIDs including COX-2 selective inhibitors
  • Minimize undesirable effects with lowest effective dose for shortest duration necessary
  • Risk factors for NSAID related gastro-intestinal complications
  • Increased frequency of adverse reactions in older people
  • Effects on cardiovascular, cerebrovascular, and renal systems

Use in Special Populations

  • Use caution and possible dosage adjustment in elderly patients
  • Not recommended for patients with moderate to severe renal impairment
  • Monitor and consider dose reduction in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms related to naproxen overdose
  • Symptoms related to esomeprazole overdose
  • Management includes symptomatic and supportive care, no specific antidotes

Therapeutic Class

  • Drugs for osteoarthritis
  • Drugs used for rheumatoid arthritis
  • Non-steroidal anti-inflammatory drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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