Anaflex Max 500 mg+20 mg (Tablet (Delayed Release))

Indications

• Relief of signs and symptoms of osteoarthritis
• Relief of signs and symptoms of rheumatoid arthritis
• Relief of signs and symptoms of ankylosing spondylitis
• Decrease the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

• Immediate release Esomeprazole Magnesium layer
• Enteric-coated Naproxen core
• Mechanism of action to inhibit prostaglandin synthesis

Dosage

• Adult dosage of 375 mg naproxen/20 mg esomeprazole
• Adult dosage of 500 mg naproxen/20 mg esomeprazole
• Adolescent dosage based on weight

Administration

• To be taken at least 30 minutes before meals
• Should not be split, chewed, crushed or dissolved

Interaction

• Concomitant use with ACE inhibitors, diuretics, and beta-blockers
• Concomitant use with warfarin
• Interference with absorption of drugs where gastric pH is important
• Effect of high-fat food on absorption

Contraindications

• Known hypersensitivity to any component of the tablet
• History of allergic reactions after taking aspirin or other NSAIDs
• Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

• Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
• Potential association with arterial thrombotic events
• Reported adverse events including gastrointestinal effects, oedema, hypertension, and cardiac failure

Pregnancy & Lactation

• Contraindicated during the third trimester of pregnancy
• Not recommended for breastfeeding mothers
• Potential impact on female fertility

Precautions & Warnings

• Avoid combination with NSAIDs and cyclooxygenase-2 selective inhibitors
• Minimum effective dose for the shortest duration necessary
• Risk factors for NSAID related gastro-intestinal complications
• Increased frequency of adverse reactions in older people
• GI bleeding, ulceration or perforation risks

Use in Special Populations

• Increased unbound plasma fraction in elderly
• Not recommended in moderate to severe renal impairment
• Monitor patients with hepatic insufficiency closely

Overdose Effects

• Symptoms and management of naproxen overdose
• Symptoms and management of esomeprazole overdose

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs used for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

• Store below 30°C
• Protect from light and moisture
• Keep out of reach of children

Related Brands

• Anaflex Max 375 mg+20 mg (Tablet (Delayed Release)) - aci-limited
• Ultranax Plus 500 mg+20 mg (Tablet (Delayed Release)) - ad-din-pharmaceuticals-ltd