Anaflex Max 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 21.00 (5 x 10: ৳ 1,050.00)
Strip Price: ৳ 210.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Aci limited
Also available as
Anaflex max 375 mg tablet

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Mechanism of action to inhibit prostaglandin synthesis

Dosage

  • Adult dosage of 375 mg naproxen/20 mg esomeprazole
  • Adult dosage of 500 mg naproxen/20 mg esomeprazole
  • Adolescent dosage based on weight

Administration

  • To be taken at least 30 minutes before meals
  • Should not be split, chewed, crushed or dissolved

Interaction

  • Concomitant use with ACE inhibitors, diuretics, and beta-blockers
  • Concomitant use with warfarin
  • Interference with absorption of drugs where gastric pH is important
  • Effect of high-fat food on absorption

Contraindications

  • Known hypersensitivity to any component of the tablet
  • History of allergic reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Potential association with arterial thrombotic events
  • Reported adverse events including gastrointestinal effects, oedema, hypertension, and cardiac failure

Pregnancy & Lactation

  • Contraindicated during the third trimester of pregnancy
  • Not recommended for breastfeeding mothers
  • Potential impact on female fertility

Precautions & Warnings

  • Avoid combination with NSAIDs and cyclooxygenase-2 selective inhibitors
  • Minimum effective dose for the shortest duration necessary
  • Risk factors for NSAID related gastro-intestinal complications
  • Increased frequency of adverse reactions in older people
  • GI bleeding, ulceration or perforation risks

Use in Special Populations

  • Increased unbound plasma fraction in elderly
  • Not recommended in moderate to severe renal impairment
  • Monitor patients with hepatic insufficiency closely

Overdose Effects

  • Symptoms and management of naproxen overdose
  • Symptoms and management of esomeprazole overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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