Esona 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.10 (5 x 10: ৳ 505.00)

Strip Price: ৳ 101.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Navana pharmaceuticals ltd
Also available as	Esona 500 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer and an enteric-coated Naproxen core
Naproxen is a NSAID with analgesic and antipyretic properties
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosing: 375 mg naproxen/20 mg of esomeprazole twice daily or 500 mg naproxen/20 mg of esomeprazole twice daily
Juvenile dosing (weight-based): 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg, and 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration with high-fat food does not affect the extent of absorption of naproxen but significantly prolongs tmax and decreases peak plasma concentration (Cmax)

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Possible risk of arterial thrombotic events, oedema, hypertension, and cardiac failure
Commonly observed adverse events include gastrointestinal issues such as peptic ulcers, bleeding, nausea, vomiting, and diarrhoea

Not recommended during the third trimester of pregnancy
Should not be used during breastfeeding
Use may impair female fertility and is not recommended in women attempting to conceive

Avoid use with other NSAIDs including cyclooxygenase-2 selective inhibitors
Minimize undesirable effects by using the lowest effective dose for the shortest duration necessary to control symptoms
Elderly and patients with renal, hepatic, or cardiovascular issues should be monitored closely during treatment

Use caution and possible dosage adjustment in elderly patients
Not recommended for use in patients with moderate to severe renal impairment
Monitor closely and consider possible dose reduction in patients with mild to moderate hepatic impairment

Symptoms may include lethargy, dizziness, epigastric pain, abdominal discomfort, heartburn, and more
Management may involve symptomatic and supportive care, and there are no specific antidotes for overdose