Inflect 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.02 (20's pack: ৳ 160.40)

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Kemiko pharmaceuticals ltd
Also available as	Inflect 500 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Immediate release Esomeprazole Magnesium layer
Enteric-coated Naproxen core
Esomeprazole is released first into the stomach
Naproxen is dissolved in the small intestine
Naproxen is a NSAID with analgesic and antipyretic properties
Naproxen inhibits prostaglandin synthesis
Esomeprazole is a proton pump inhibitor
Esomeprazole suppresses gastric acid secretion
Esomeprazole specifically inhibits the H+/k+ -ATPase in the gastric parietal cell
Esomeprazole blocks the final step in acid production

Use the lowest effective dose for the shortest duration
Recommended dosage for adults with rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
Recommended dosage for juvenile idiopathic arthritis in adolescent patients
Different treatment should be considered if a lower dose of Esomeprazole is appropriate

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen and Esomeprazole together with high-fat food may affect the absorption of naproxen

Known hypersensitivity to any component of the tablet or substituted benzimidazoles
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Possible association with a small increased risk of arterial thrombotic events
Reported adverse events include gastrointestinal issues, oedema, hypertension, and cardiac failure

Avoid combination with NSAIDs including cyclooxygenase-2 selective inhibitors
Use caution in patients with high age, concomitant use of anticoagulants, corticosteroids, or other NSAIDs
Increased risk of adverse reactions in older people
Gastrointestinal bleeding, ulceration, or perforation may occur
Special consideration in patients with conditions like Inducible porphyries, Systemic lupus erythematosus and mixed connective tissue disease
Appropriate monitoring and advice required for patients with a history of hypertension and/or mild to moderate congestive heart failure
Long-term administration may result in renal papillary necrosis and other renal injury