Inflect 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.03 (20's pack: ৳ 200.60)

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Kemiko pharmaceuticals ltd
Also available as	Inflect 375 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Use the lowest effective dose for the shortest duration
Adults: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Adolescent Patients 12 Years of Age and Older: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg
Adolescent Patients 12 Years of Age and Older: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole inhibits gastric acid secretion and may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen and Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Gastric ulcers
NSAID associated upper gastrointestinal adverse events
Arterial thrombotic events
Oedema
Hypertension
Cardiac failure
Gastrointestinal adverse events such as nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis, Crohn’s disease, gastritis

Avoid combination with NSAIDs including cyclooxygenase-2 selective inhibitors
Use the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors to develop NSAID related gastro-intestinal complications
Increased frequency of adverse reactions in older people
Gastrointestinal bleeding, ulceration or perforation which can be fatal has been reported with all NSAIDs at any time during treatment

Caution in elderly patients
Not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, and more
Patients should be managed by symptomatic and supportive care following a NSAID overdose
No specific antidote is known for esomeprazole overdose