Naxin Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Opsonin pharma ltd
Also available as
Naxin plus 500 mg tablet

Title

  • Naproxen & Esomeprazole Tablet

Categories

  • Medicine
  • Pharmaceuticals

Description

  • A combination tablet indicated for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and to decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers.
  • This tablet consists of an immediate release esomeprazole magnesium layer and an enteric-coated naproxen core, with the esomeprazole released first into the stomach before the dissolution of naproxen in the small intestine.
  • The dosage varies for different conditions and age groups, with specific doses for adults, adolescent patients, and precautions for pregnant and breastfeeding women.
  • It is important not to split, chew, crush or dissolve the tablet, and to take it at least 30 minutes before meals.
  • Possible drug interactions include those with other NSAIDs, warfarin, and medications affected by changes in gastric pH due to esomeprazole.
  • The tablet is contraindicated for individuals with known hypersensitivity to its components, a history of asthma, urticaria, or allergic-type reactions to aspirin or other NSAIDs, and use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery.
  • The tablet has been shown to decrease the occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events compared to naproxen alone.
  • Use during pregnancy, lactation, in elderly patients, and those with renal or hepatic impairment requires careful consideration and monitoring.
  • Overdose effects include symptoms related to both naproxen and esomeprazole overdoses, with management involving symptomatic and supportive care as there are no specific antidotes.
  • Storage conditions recommend storing the medication at a temperature below 30°C, protected from light and moisture, and out of reach of children.

Color Options

  • Tablet color may vary based on manufacturer

Dimensions

  • Standard tablet size

Dosage Forms

  • Oral tablet

Packaging

  • Bottle or blister pack

Composition

  • Combination of naproxen and esomeprazole

Functions

  • Relieves signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and decreases the risk of developing gastric ulcers
  • Inhibits prostaglandin synthesis, suppresses gastric acid secretion
  • Decreases the occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events

Materials

  • Active ingredients: Naproxen, Esomeprazole Magnesium; Inactive ingredients: Cellulose, Corn Starch, Iron Oxide, Magnesium Stearate

Technical Specifications

  • Immediate release esomeprazole magnesium layer, enteric-coated naproxen core

Design Elements

  • Biconvex, round tablet

Usability Features

  • Should be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
  • Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Gastrointestinal side effects, occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Possibility of arterial thrombotic events, oedema, hypertension, and cardiac failure
  • Common adverse events include gastrointestinal issues such as peptic ulcers, perforation or GI bleeding, and nausea, vomiting, diarrhea, among others
  • Less frequent adverse events include gastritis and exacerbation of colitis and Crohn's disease

Pregnancy & Lactation

  • Not recommended for use during the third trimester of pregnancy and while breastfeeding
  • Potential to impair female fertility
  • In women attempting to conceive or during the first and second trimester of pregnancy, use only if potential benefit outweighs the risk

Precautions & Warnings

  • Avoid combining with other NSAIDs or cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects by using the lowest effective dose for the shortest duration necessary to control symptoms
  • Consider combination therapy with protective agents in patients at high risk for GI bleeding, ulceration, or perforation

Use in Special Populations

  • Caution in elderly patients, those with moderate to severe renal impairment, and hepatic insufficiency

Overdose Effects

  • Symptoms related to both naproxen and esomeprazole overdose
  • No specific antidotes, management involves symptomatic and supportive care

Therapeutic Class

  • Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C, protect from light & moisture

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