Naxin Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.50 (3 x 10: ৳ 375.00)
Strip Price: ৳ 125.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Opsonin pharma ltd
Also available as
Naxin plus 375 mg tablet

Indications

  • Relief of signs and symptoms of Osteoarthritis
  • Relief of signs and symptoms of Rheumatoid arthritis
  • Relief of signs and symptoms of Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis

Dosage

  • Adult dosage: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
  • Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg
  • Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Administration

  • Tablet is to be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
  • Inhibition of gastric acid secretion, may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Known hypersensitivity to any component of this tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Gastrointestinal adverse events
  • Increased risk of arterial thrombotic events
  • Oedema, hypertension and cardiac failure

Pregnancy & Lactation

  • Not recommended for use during the third trimester of pregnancy
  • Should not be used during breastfeeding
  • Use may impair female fertility
  • Lower risk during the first and second trimester of pregnancy

Precautions & Warnings

  • Should be avoided in combination with NSAIDs including cyclooxygenase-2 selective inhibitors
  • Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
  • Caution in patients with conditions such as Inducible porphyries, Systemic lupus erythematosis and mixed connective tissue disease
  • Risk factors to develop NSAID related gastro-intestinal complications include high age, concomitant use of anticoagulants, corticosteroids, other NSAIDs including low-dose acetylsalicylic acid

Use in Special Populations

  • Use caution when high doses are required and some adjustment of dosage may be required in elderly patients
  • Not recommended for use in patients with moderate or severe renal impairment
  • Not recommended in patients with severe hepatic impairment

Overdose Effects

  • Symptoms such as lethargy, dizziness, drowsiness, abdominal pain, renal dysfunction
  • Symptoms described in connection with deliberate esomeprazole overdose are transient
  • No specific antidote is known

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature of below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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