Napro-A Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Acme laboratories ltd
Also available as
Napro a plus 500 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers

Pharmacology

  • Naproxen & Esomeprazole combination
  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Mechanism of action of Naproxen to inhibit prostaglandin synthesis
  • Proton pump inhibitor property of Esomeprazole to suppress gastric acid secretion

Dosage

  • Use lowest effective dose
  • Tablet strength options for different conditions and age groups

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush or dissolve the tablet

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use with warfarin may increase risk of bleeding
  • Interference with absorption of drugs such as Ketoconazole, iron salts, and digoxin
  • Effect of high-fat food on absorption of naproxen & esomeprazole

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and upper gastrointestinal adverse events
  • Gastrointestinal side effects from Naproxen
  • Hypertension, cardiac failure, and oedema reported
  • Gastrointestinal adverse events from coxibs and some NSAIDs
  • Increased risk of arterial thrombotic events with high doses of NSAIDs
  • Gastric bleeding and ulceration, gastrointestinal infections

Pregnancy & Lactation

  • Use caution in pregnancy and avoid during third trimester
  • Excretion in human milk
  • Impact on fertility in women
  • Safety considerations in breastfeeding

Precautions & Warnings

  • Avoid combination with other NSAIDs, cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects by using the lowest effective dose
  • Risk factors for gastrointestinal complications
  • Age-related frequency of adverse reactions
  • Gastrointestinal, cardiovascular, cerebrovascular, and renal effects
  • Consideration for elderly patients, renal impairment, and hepatic insufficiency

Use in Special Populations

  • Special considerations for elderly patients, patients with renal impairment, and hepatic insufficiency

Overdose Effects

  • Symptoms related to Naproxen and Esomeprazole overdose
  • Management of overdose symptoms

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Temperature storage requirement below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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