Napro-A Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Acme laboratories ltd
Also available as
Napro a plus 375 mg tablet

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Reducing the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Naproxen is an NSAID with analgesic and antipyretic properties
  • Mechanism of action of Naproxen is to inhibit prostaglandin synthesis
  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell
  • Reduces gastric acidity

Dosage

  • Use the lowest effective dose
  • Adult dosage: One tablet twice daily of either 375mg naproxen/20mg esomeprazole or 500mg naproxen/20mg esomeprazole
  • Juvenile dosage: Based on weight

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
  • Concomitant use with warfarin may result in increased risk of bleeding
  • Inhibition of drug absorption by Esomeprazole

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmatic or allergic-type reactions after taking aspirin or other NSAIDs
  • Use during peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side effects

  • Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • Possible side effects include gastrointestinal issues, arterial thrombotic events, oedema, hypertension, cardiac failure

Pregnancy and lactation

  • Not recommended during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions and warnings

  • Avoid use of Naproxen and NSAIDs together
  • Minimize undesirable effects by using the lowest effective dose
  • Special caution for older people
  • Increased risk of gastrointestinal bleeding and perforation
  • Monitoring and advice required for patients with a history of hypertension and/or congestive heart failure
  • Potential impact on renal function

Use in special populations

  • Caution required in elderly patients
  • Not recommended for patients with moderate to severe or severe renal impairment
  • Close monitoring and possible dose reduction in patients with mild to moderate hepatic impairment

Overdose effects

  • Symptoms of Naproxen overdose such as lethargy, dizziness, gastrointestinal issues, renal dysfunction
  • Forced diuresis, alkalinization of urine may not be useful for Naproxen overdose
  • No specific antidote known for Esomeprazole overdose

Therapeutic class

  • Drugs for osteoarthritis
  • Drugs used for rheumatoid arthritis
  • Non-steroidal anti-inflammatory drugs (NSAIDs)

Storage conditions

  • Store at temperature below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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