Naprosyn Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 17.00 (5 x 10: ৳ 850.00)
Strip Price: ৳ 170.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Radiant pharmaceuticals ltd
Also available as
Naprosyn plus 500 mg tablet

Indications

  • Relief of signs & symptoms of Osteoarthritis
  • Relief of signs & symptoms of Rheumatoid arthritis
  • Relief of signs & symptoms of Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer & enteric-coated Naproxen core
  • Naproxen is a NSAID with analgesic & antipyretic properties
  • Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell

Dosage

  • Adults: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
  • Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg, 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Administration

  • Tablet is to be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Increased risk of bleeding complication with warfarin
  • Potential interference with the absorption of drugs like Ketoconazole, iron salts and digoxin
  • Effects of administration with high-fat food on absorption of naproxen

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • Possible association with risk of arterial thrombotic events
  • Adverse events include gastrointestinal symptoms, oedema, hypertension, cardiac failure

Pregnancy & Lactation

  • Not recommended during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • Potential impairment of female fertility

Precautions & Warnings

  • Risk factors for developing NSAID related gastro-intestinal complications
  • Increased frequency of adverse reactions in older people
  • Risk of GI bleeding, ulceration or perforation with NSAIDs
  • Monitoring required for patients with history of hypertension and/or mild to moderate congestive heart failure

Use in Special Populations

  • Caution and dosage adjustment in elderly patients
  • Not recommended for use in patients with moderate to severe or severe renal impairment
  • Close monitoring in patients with hepatic insufficiency

Overdose Effects

  • Symptoms related to Naproxen overdose
  • Transient symptoms related to esomeprazole overdose
  • No specific antidotes for either component
  • Use of symptomatic and supportive care

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature of below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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