Naprotec 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Sharif pharmaceuticals ltd
Also available as
Naprotec 500 mg tablet

Title and Categories

  • Naproxen & Esomeprazole Tablet
  • Pain Relief Medication
  • Gastric Ulcer Prevention
  • NSAID with Gastric Acid Inhibitor

Dosage and Administration

  • Recommended Dosage: One tablet twice daily
  • Adult Dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole
  • Adolescent Dosage (Weight > 50 kg): 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole
  • Adolescent Dosage (Weight 38 kg to < 50 kg): 375 mg naproxen/20 mg esomeprazole
  • Administration: Take at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Indications

  • Relief of Osteoarthritis signs and symptoms
  • Relief of Rheumatoid Arthritis signs and symptoms
  • Relief of Ankylosing Spondylitis signs and symptoms
  • Decrease in risk of developing gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis
  • Suppression of gastric acid secretion

Interaction

  • Concomitant use of NSAIDs may reduce antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
  • Concomitant use with warfarin may increase risk of bleeding
  • Inhibition of gastric acid secretion may interfere with drug absorption
  • Administration with high-fat food prolongs time to reach peak plasma concentration

Contraindications

  • Known hypersensitivity to tablet components
  • History of allergic-type reactions to aspirin or other NSAIDs
  • Use during peri-operative period in coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events
  • Possible increased risk of arterial thrombotic events
  • Reported adverse events: hypertension, cardiac failure, GI bleeding, nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain

Pregnancy and Lactation

  • Not recommended during third trimester of pregnancy
  • Should not be used during breastfeeding
  • May impair female fertility

Precautions and Warnings

  • Avoid use with other NSAIDs
  • Use lowest effective dose for shortest duration
  • Patients with cardiovascular or cerebrovascular diseases should use with caution
  • Long-term treatment requires regular surveillance

Use in Special Populations

  • Use caution and possible dosage adjustment in elderly patients
  • Not recommended for patients with moderate to severe renal impairment
  • Monitor patients with mild to moderate hepatic impairment closely

Overdose Effects

  • Symptoms: lethargy, dizziness, abdominal discomfort, renal dysfunction, hypertension
  • No specific antidotes, manage with supportive care

Therapeutic Class

  • Osteoarthritis Drugs
  • Rheumatoid Arthritis Drugs
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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