Naprox Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (4 x 10: ৳ 600.00)

Strip Price: ৳ 150.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Eskayef pharmaceuticals ltd
Also available as	Naprox plus 375 mg tablet

Relief of signs & symptoms of osteoarthritis
Relief of signs & symptoms of rheumatoid arthritis
Relief of signs & symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Mechanism of action of Naproxen to inhibit prostaglandin synthesis
Esomeprazole as a proton pump inhibitor that suppresses gastric acid secretion

Use lowest effective dose for the shortest duration consistent with individual patient treatment goals
Dosage for adults: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Dosage for Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decrease in the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
Gastrointestinal side effects from Naproxen
Increased risk of arterial thrombotic events with use of coxibs and some NSAIDs

Naproxen and Esomeprazole tablet should not be given during the first and second trimester of pregnancy unless the potential benefit to the patient outweighs the potential risk to the foetus
Naproxen and Esomeprazole tablet is contraindicated during the third trimester of pregnancy
Naproxen and Esomeprazole tablet should not be used during breastfeeding

The combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided
Use the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors to develop NSAID related gastro-intestinal complications

Use caution when high doses are required & some adjustment of dosage may be required in elderly patients
Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely