Naproxen Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Zenith pharmaceuticals ltd
Also available as
Naproxen plus 500 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Gastric ulcers risk reduction

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibits prostaglandin synthesis
  • Suppresses gastric acid secretion

Dosage

  • Use lowest effective dose
  • Adult dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole twice daily
  • Adolescent dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole

Administration

  • Take at least 30 minutes before meals

Interaction

  • Reduced antihypertensive effect with certain medicines
  • Increased risk of bleeding complication with warfarin
  • Interference with the absorption of certain drugs
  • Effect of high-fat food on absorption

Contraindications

  • Hypersensitivity to any component
  • History of allergic-type reactions after taking aspirin or other NSAIDs
  • Use during peri-operative period in CABG surgery

Side Effects

  • Decreased incidence of gastrointestinal side effects
  • Decreased occurrence of gastric ulcers
  • Gastrointestinal adverse events reduction
  • Potential risk of arterial thrombotic events
  • Gastrointestinal effects such as GI bleeding, perforation, or ulceration

Pregnancy & Lactation

  • Contraindicated in 3rd trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions & Warnings

  • Avoid with other NSAIDs
  • Minimize undesirable effects with lowest effective dose
  • Consider combination therapy for high-risk patients
  • Regular surveillance for long-term treatment
  • Increased frequency of adverse reactions in older people
  • Cardiovascular and cerebrovascular effects monitoring
  • Renal effects monitoring

Use in Special Populations

  • Increased unbound plasma fraction in elderly patients
  • Not recommended for patients with moderate or severe renal impairment
  • Close monitoring for patients with mild to moderate hepatic insufficiency

Overdose Effects

  • Symptoms related to Naproxen overdose
  • Symptoms related to esomeprazole overdose
  • Management options for overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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