Nasopain 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (5 x 6: ৳ 390.00)

Strip Price: ৳ 78.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Jenphar bangladesh ltd
Also available as	Nasopain 500 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Esomeprazole is released first into the stomach, prior to the dissolution of Naproxen in the small intestine
Naproxen is a NSAID with analgesic & antipyretic properties
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H⁺/k⁺ -ATPase in the gastric parietal cell

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adults: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
Adolescent Patients 12 Years of Age & Older: Varying dosage based on weight

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen & Esomeprazole together with high-fat food does not affect the extent of absorption of naproxen

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Naproxen and Esomeprazole tablet has been shown to significantly decrease the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Clinical trial and epidemiological data suggest that use of coxibs and some NSAIDs may be associated with a small increased risk of arterial thrombotic events
Oedema, hypertension, and cardiac failure have been reported in association with NSAID treatment

Avoid the combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms

Use caution when high doses are required in elderly patients
Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms related to Naproxen overdose include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alterations in liver function, hypoprothrombinemia, renal dysfunction, and more
Management should be symptomatic and supportive care following a NSAID overdose