Neso 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (5 x 10: ৳ 650.00)
Strip Price: ৳ 130.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Aristopharma ltd
Also available as
Neso 500 mg tablet

Indications

  • relief of signs and symptoms of osteoarthritis
  • relief of signs and symptoms of rheumatoid arthritis
  • relief of signs and symptoms of ankylosing spondylitis
  • decrease the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Pharmacology

  • consists of immediate release Esomeprazole Magnesium layer and enteric-coated Naproxen core
  • Naproxen is a NSAID with analgesic and antipyretic properties
  • Esomeprazole is a proton pump inhibitor which suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell

Dosage

  • use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
  • adult dosage: one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole

Administration

  • tablet is to be taken at least 30 minutes before meals
  • do not split, chew, crush or dissolve the tablet

Interaction

  • concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics and beta-blockers
  • concomitant use with warfarin may result in an increased risk of a bleeding complication
  • esomeprazole may interfere with absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
  • use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • possible small increased risk of arterial thrombotic events
  • gastrointestinal adverse events such as peptic ulcers, GI bleeding, nausea, vomiting, diarrhea, etc.

Pregnancy and Lactation

  • contraindicated during the third trimester of pregnancy
  • should not be used during breastfeeding
  • use of NSAIDs like Naproxen may impair female fertility

Precautions and Warnings

  • avoid combination with other NSAIDs
  • minimize undesirable effects by using the lowest effective dose for the shortest duration necessary to control symptoms
  • increased frequency of adverse reactions in older people, especially gastrointestinal bleeding and perforation

Use in Special Populations

  • use caution and possible dosage adjustment in elderly patients
  • not recommended for use in patients with moderate to severe or severe renal impairment
  • monitor patients with mild to moderate hepatic impairment closely

Overdose Effects

  • symptoms may include lethargy, dizziness, epigastric pain, gastrointestinal bleeding, renal dysfunction, etc.
  • no specific antidote, management should be symptomatic and general supportive measures should be utilized

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • store at temperature below 30°C
  • protect from light and moisture
  • keep out of reach of children

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