Neso 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (5 x 10: ৳ 750.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Aristopharma ltd
Also available as
Neso 375 mg tablet

Indications

  • Relief of osteoarthritis symptoms
  • Relief of rheumatoid arthritis symptoms
  • Relief of ankylosing spondylitis symptoms
  • Reduction of risk of developing gastric ulcers

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer
  • Consists of enteric-coated Naproxen core
  • Esomeprazole released first into stomach
  • Dissolution of Naproxen in small intestine
  • Naproxen: NSAID with analgesic & antipyretic properties
  • Mechanism of action of Naproxen: inhibits prostaglandin synthesis
  • Esomeprazole: proton pump inhibitor that suppresses gastric acid secretion

Dosage

  • Use lowest effective dose for shortest duration
  • Recommended dosage for adults
  • Recommended dosage for adolescent patients 12 years of age & older

Administration

  • Tablet should not be split, chewed, crushed or dissolved
  • Take at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of tablet and warfarin may increase risk of bleeding complication
  • Esomeprazole may interfere with absorption of certain drugs
  • Administration with high-fat food prolongs time to peak plasma concentration

Contraindications

  • Known hypersensitivity to any component of the tablet
  • History of asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs
  • Use during peri-operative period in setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased incidence of gastrointestinal side effects from Naproxen
  • Significantly decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Possible increased risk of arterial thrombotic events
  • Reported adverse events: nausea, vomiting, diarrhoea, ulcerative stomatitis, GI bleeding
  • Less frequently observed adverse event: gastritis
  • Oedema, hypertension and cardiac failure reported in association with NSAID treatment

Pregnancy & Lactation

  • Not recommended during first and second trimester of pregnancy
  • Contraindicated during third trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions & Warnings

  • Avoid combination with NSAIDs and cyclooxygenase-2 selective inhibitors
  • Use with low dose acetylsalicylic acid
  • Minimize undesirable effects by using lowest effective dose for shortest duration
  • Risk-factors for developing NSAID related gastro-intestinal complications
  • Increased risk of adverse reactions in older people
  • Increased risk of GI bleeding, ulceration or perforation
  • Appropriate monitoring and advice required for patients with history of hypertension and/or mild to moderate congestive heart failure
  • Renal effects: potential renal papillary necrosis and other renal injury

Use in Special Populations

  • Studies indicate unbound plasma fraction of Naproxen is increased in the elderly
  • Not recommended in patients with moderate or severe renal impairment
  • Monitor patients with mild to moderate hepatic impairment closely

Overdose Effects

  • Symptoms of Naproxen overdose: lethargy, dizziness, epigastric pain, gastrointestinal bleeding
  • Symptoms of esomeprazole overdose: transient symptoms
  • Management: symptomatic and supportive care, no specific antidote known

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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