Novoxen 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (5 x 4: ৳ 260.00)

Strip Price: ৳ 52.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Orion pharma ltd
Also available as	Novoxen 375 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer
Consists of an enteric-coated Naproxen core
Mechanism of action of Naproxen is to inhibit prostaglandin synthesis
Esomeprazole suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosage: one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg
Adolescent dosage: one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Tablet is to be taken at least 30 minutes before meals

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics, and beta-blockers
Concomitant use with warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Known hypersensitivity to any component of the tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Naproxen and Esomeprazole tablet has been shown to decrease the occurrence of gastric ulcers and NSAID-associated upper gastrointestinal adverse events compared to Naproxen alone
Clinical trial and epidemiological data suggest that use of coxibs and some NSAIDs may be associated with a small increased risk of arterial thrombotic events
Oedema, hypertension, and cardiac failure have been reported in association with NSAID treatment
Peptic ulcers, perforation, or GI bleeding, sometimes fatal, particularly in older people, may occur
Other adverse events include nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis, and Crohn’s disease

Avoid combination with NSAIDs including cyclooxygenase-2 selective inhibitors
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors to develop NSAID related gastro-intestinal complications include high age, concomitant use of anticoagulants, and corticosteroids

Elderly patients: use caution when high doses are required, and some adjustment of dosage may be required
Patients with Moderate to Severe Renal impairment: not recommended for use
Hepatic insufficiency: monitor patients with mild to moderate hepatic impairment closely

Symptoms include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, and nausea
Management involves symptomatic and supportive care, including emesis and/or activated charcoal