Nupralgin Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)

Strip Price: ৳ 80.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Ibn sina pharmaceuticals ltd
Also available as	Nupralgin plus 500 mg tablet

Relief of signs & symptoms of osteoarthritis
Relief of signs & symptoms of rheumatoid arthritis
Relief of signs & symptoms of ankylosing spondylitis
Decreasing the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Naproxen is a NSAID with analgesic & antipyretic properties
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion

Carefully consider potential benefits & risks before use
Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosage: one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole, or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage (weight greater than 50 kg): 375 mg naproxen/20 mg of esomeprazole, or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage (weight 38 kg to less than 50 kg): one tablet twice daily of 375 mg naproxen/20 mg of esomeprazole

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is important for bioavailability (eg. Ketoconazole, iron salts, digoxin)
Administration with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs time to reach peak plasma concentration and decreases peak plasma concentration

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Includes decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Risks of arterial thrombotic events associated with long-term, high-dose use
Possible adverse events such as oedema, hypertension, cardiac failure, gastrointestinal effects (nausea, vomiting, etc.)

Not recommended during first and second trimester of pregnancy unless potential benefit outweighs potential risk
Contraindicated during the third trimester of pregnancy
Not recommended during breastfeeding

Avoid combination with other NSAIDs
Minimize undesirable effects by using lowest effective dose for the shortest duration necessary
Increased risk of serious NSAID-related adverse events in older people
Consider combination therapy with protective agents for patients with history of ulcer or requiring concomitant low-dose acetylsalicylic acid
Caution advised in patients receiving NSAIDs with concomitant medications that could increase risk of ulceration or bleeding
Appropriate monitoring and advice required for patients with history of hypertension and/or mild to moderate congestive heart failure
Regular surveillance recommended for long-term treatment, especially for those treated for more than a year

Use with caution in elderly patients and consider the lowest effective dose
Not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms of naproxen overdose include lethargy, dizziness, drowsiness, gastrointestinal symptoms, alterations in liver function, and more
Symptoms of esomeprazole overdose are transient
Management involves symptomatic and supportive care, no specific antidotes