Nupralgin Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Ibn sina pharmaceuticals ltd
Also available as	Nupralgin plus 375 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Esomeprazole is released first into the stomach prior to the dissolution of Naproxen in the small intestine
Naproxen is an NSAID with analgesic & antipyretic properties
Naproxen inhibits the prostaglandin synthesis
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+ -ATPase

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Different dose options for adults and juvenile idiopathic arthritis in adolescent patients
Tablet to be taken at least 30 minutes before meals

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Inhibition of gastric acid secretion & interference with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen
Prolongs Tmax by 10 hours and decreases Cmax by about 12%

Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease
Less frequently, gastritis has been observed

Tablet should not be given unless the potential benefit to the patient outweighs the potential risk to the foetus
Naproxen and Esomeprazole tablet is contraindicated during the third trimester of pregnancy
Naproxen is excreted in low quantities in human milk. Esomeprazole excretion in human milk is unknown
Use of NSAIDs like Naproxen may impair female fertility. The use of Naproxen and Esomeprazole tablet is not recommended in women attempting to conceive

Avoid combination of Naproxen and Esomeprazole tablet with NSAIDs including cyclooxygenase-2 selective inhibitors
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
Risk-factors to develop NSAID related gastro-intestinal complications should be considered
Caution advised in patients receiving NSAIDs with concomitant medications which could increase the risk of ulceration or bleeding

Use caution and consider dose adjustment in elderly patients
Products not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely
Not recommended in patients with severe hepatic impairment

Symptoms related to Naproxen overdose including lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alterations in liver function, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, and vomiting
Symptoms related to esomeprazole overdose are transient
No specific antidotes, treatment should be symptomatic and general supportive measures