Solivo 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (5 x 6: ৳ 390.00)

Strip Price: ৳ 78.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Healthcare pharmaceuticals ltd
Also available as	Solivo 500 mg tablet

Relief of signs & symptoms of osteoarthritis
Relief of signs & symptoms of rheumatoid arthritis
Relief of signs & symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Use the lowest effective dose for the shortest duration
Adult dosage: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Adolescent dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Juvenile dosage: 375 mg naproxen/20 mg of esomeprazole

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decrease the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Clinical trial and epidemiological data suggest that use of coxibs and some NSAIDs may be associated with a small increased risk of arterial thrombotic events
Gastrointestinal side effects: nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia
Peptic ulcers, perforation or GI bleeding, particularly in older people, may occur

Naproxen and Esomeprazole tablet should not be given during the first and second trimester of pregnancy unless the potential benefit to the patient outweighs the potential risk to the foetus
Naproxen and Esomeprazole tablet is contraindicated during the third trimester of pregnancy
Naproxen and Esomeprazole tablet should not be used during breastfeeding

Avoid combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
Consideration for patients requiring concomitant low dose acetylsalicylic acid
Caution advised in patients receiving NSAIDs with concomitant medications which could increase the risk of ulceration or bleeding

Use caution in elderly patients
Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms of Naproxen overdose: lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort
Symptoms of esomeprazole overdose are transient
Management for Naproxen overdose: symptomatic and supportive care
No specific antidote for Esomeprazole overdose