Solivo 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (5 x 6: ৳ 450.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Healthcare pharmaceuticals ltd
Also available as
Solivo 375 mg tablet

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis by Naproxen
  • Specific inhibition of the H+/k+ -ATPase in the gastric parietal cell by Esomeprazole
  • Reduction of gastric acidity by Esomeprazole

Dosage

  • Use the lowest effective dose
  • Adult dosage: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
  • Juvenile Idiopathic Arthritis dosage: Varies based on weight

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
  • Interference with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Known hypersensitivity to any component of this tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Increased risk of arterial thrombotic events
  • Gastrointestinal adverse events
  • Oedema, hypertension, and cardiac failure

Pregnancy & Lactation

  • Not recommended during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions & Warnings

  • Avoid the combination of this tablet and NSAIDs including cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects by using the lowest effective dose
  • Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms

Use in Special Populations

  • Use caution and possible dosage adjustment in elderly patients
  • Not recommended for use in patients with moderate to severe or severe renal impairment
  • Close monitoring and possible dose reduction in patients with mild to moderate hepatic impairment

Overdose Effects

  • Related to Naproxen overdose
  • Related to Esomeprazole overdose
  • Symptomatic and supportive care following a NSAID overdose
  • No specific antidote

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at a temperature of below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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