Xenole 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 13.00 (3 x 10: ৳ 390.00)
Strip Price: ৳ 130.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Square pharmaceuticals plc
Also available as
Xenole 500 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Decrease in risk of gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis
  • Proton pump inhibitor

Dosage

  • Use lowest effective dose
  • Adult dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole twice daily
  • Adolescent dosage based on weight

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush, or dissolve the tablet

Interaction

  • Reduced antihypertensive effect with NSAIDs
  • Increased risk of bleeding with warfarin
  • Interference with drug absorption
  • Effect of high-fat food on absorption

Contraindications

  • Hypersensitivity
  • History of allergic-type reactions to NSAIDs
  • Use during peri-operative period in CABG surgery

Side Effects

  • Decreased occurrence of gastric ulcers
  • Increased risk of arterial thrombotic events
  • Gastrointestinal adverse events
  • Oedema, hypertension, cardiac failure
  • Gastrointestinal symptoms

Pregnancy & Lactation

  • Contraindicated in third trimester
  • Excretion in human milk
  • Impaired female fertility

Precautions & Warnings

  • Avoid use with other NSAIDs
  • Use with low dose acetylsalicylic acid
  • Minimize dose and duration
  • Risk-factors for gastrointestinal complications
  • Caution in older people
  • Cardiovascular and cerebrovascular effects
  • Renal effects

Use in Special Populations

  • Caution in elderly patients
  • Not recommended in patients with moderate to severe renal impairment
  • Monitoring in patients with hepatic insufficiency

Overdose Effects

  • Symptoms of Naproxen and Esomeprazole overdose
  • Symptomatic and supportive care for treatment

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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