Duofix 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Osl pharma limited
Also available as
Duofix 500 mg tablet

Indications

  • Relief of signs & symptoms of Osteoarthritis
  • Relief of signs & symptoms of Rheumatoid arthritis
  • Relief of signs & symptoms of Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Consists of an immediate release Esomeprazole Magnesium layer
  • Consists of an enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis by Naproxen
  • Suppression of gastric acid secretion by Esomeprazole

Dosage

  • Use the lowest effective dose for the shortest duration
  • Dosage for Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis
  • Dosage for Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older

Administration

  • Tablet should not be split, chewed, crushed or dissolved
  • To be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use of the tablet and warfarin may result in increased risk of a bleeding complication
  • Inhibition of gastric acid secretion by Esomeprazole may interfere with the absorption of certain drugs

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Naproxen and Esomeprazole tablet has been shown to significantly decrease the occurrence of gastric ulcers
  • NSAID use may be associated with a small increased risk of arterial thrombotic events
  • Gastrointestinal adverse events may occur with NSAID use

Pregnancy & Lactation

  • Naproxen and Esomeprazole tablet should not be given during the first and second trimester of pregnancy unless the potential benefit outweighs the potential risk
  • Naproxen and Esomeprazole tablet is contraindicated during the third trimester of pregnancy
  • Naproxen and Esomeprazole tablet should not be used during breastfeeding

Precautions & Warnings

  • The combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided
  • Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary
  • Risk-factors to develop NSAID related gastro-intestinal complications include high age, concomitant use of anticoagulants, corticosteroids, other NSAIDs including low-dose acetylsalicylic acid, debilitating cardiovascular disease

Use in Special Populations

  • Use caution when high doses are required in elderly patients
  • Naproxen-containing products are not recommended for use in patients with moderate to severe renal impairment
  • Monitor patients with mild to moderate hepatic impairment closely

Overdose Effects

  • Symptoms associated with Naproxen overdose
  • Symptoms associated with esomeprazole overdose
  • Management of overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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