Duofix 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)

Strip Price: ৳ 120.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Osl pharma limited
Also available as	Duofix 375 mg tablet

Relief of signs & symptoms of Osteoarthritis
Relief of signs & symptoms of Rheumatoid arthritis
Relief of signs & symptoms of Ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Adolescent Patients 12 Years of Age & Older: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole if weight greater than 50 kg
Adolescent Patients 12 Years of Age & Older: One tablet twice daily of 375 mg naproxen/20 mg of esomeprazole if weight 38 kg to less than 50 kg

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Inhibition of gastric acid secretion by Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Increased risk of arterial thrombotic events with use of coxibs and some NSAIDs
Commonly observed gastrointestinal adverse events
Oedema, hypertension and cardiac failure in association with NSAID treatment
Gastrointestinal bleeding, ulceration or perforation, particularly in older people, may occur

Avoid combination with NSAIDs including cyclooxygenase-2 selective inhibitors
Minimize undesirable effects by using the lowest effective dose for the shortest duration necessary to control symptoms
Increased frequency of adverse reactions especially gastrointestinal bleeding, and perforation in older people
Consider combination therapy with protective agents for patients with history of GI toxicity
Caution advised in patients receiving NSAIDs with concomitant medications which could increase the risk of ulceration or bleeding
Appropriate monitoring and advice required for patients with a history of hypertension and/or mild to moderate congestive heart failure
Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury

Increased unbound plasma fraction of naproxen in the elderly
Not recommended for use in patients with moderate to severe or severe renal impairment
Use with caution and possible dose reduction based on hepatic impairment

Symptoms of Naproxen overdose include lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, etc.
Symptoms of Esomeprazole overdose are transient
Management involves symptomatic and supportive care, there are no specific antidotes