Emaprox 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)
Strip Price: ৳ 115.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Globe pharmaceuticals ltd
Also available as
Emaprox 375 mg tablet

Indications

  • Relief of signs & symptoms of Osteoarthritis
  • Relief of signs & symptoms of Rheumatoid arthritis
  • Relief of signs & symptoms of Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Consists of an immediate release Esomeprazole Magnesium layer and an enteric-coated Naproxen core
  • Naproxen - NSAID with analgesic and antipyretic properties, inhibits prostaglandin synthesis
  • Esomeprazole - Proton pump inhibitor, suppresses gastric acid secretion by inhibition of the H+/k+ -ATPase

Dosage

  • Use lowest effective dose for the shortest duration consistent with individual patient treatment goals
  • Adults - One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
  • Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age and Older - Varying dosage based on weight

Administration

  • Do not split, chew, crush or dissolve the tablet
  • Take at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics and beta-blockers
  • Concomitant use with warfarin may result in increased risk of a bleeding complication
  • Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • Administration with high-fat food may affect absorption of naproxen

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of hypersensitivity reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
  • Possible association with arterial thrombotic events, oedema, hypertension, cardiac failure, gastrointestinal adverse events

Pregnancy & Lactation

  • Use not recommended during the first and second trimester of pregnancy
  • Contraindicated during the third trimester of pregnancy
  • Not recommended during breastfeeding
  • Possible impairment of female fertility

Precautions & Warnings

  • Avoid combination with NSAIDs including cyclooxygenase-2 selective inhibitors
  • Use with low dose acetylsalicylic acid may minimize undesirable effects
  • Increased risk factors for developing NSAID-related complications in certain patients

Use in Special Populations

  • Caution and possible dosage adjustments in elderly patients
  • Not recommended in patients with moderate to severe renal impairment
  • Close monitoring and possible dose reduction in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms of Naproxen overdose may include lethargy, dizziness, drowsiness, gastrointestinal discomfort, and renal dysfunction
  • Management includes symptomatic and supportive care, emesis, activated charcoal, and osmotic cathartic

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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