Pefla 400 mg (Tablet)

Indications

• Gastrointestinal infection
• Urinary tract infection
• Respiratory tract infection
• Ear, nose and throat infection
• Bone and joint infection
• Skin and soft tissue infection
• Pelvic infection
• Abdominal and hepatobiliary infection
• Septicemia
• Bacteraemia
• Gonorrhea
• Endocarditis
• Meningitis

Pharmacology

Synthetic antibacterial agent

Mode of Action

Inhibition of subunit-A of DNA gyrase (Topoisomerase II)

Dosage & Administration

• Adult with normal hepatic function: 400 mg tablet 12 hourly with meals
• Initial loading dose of 800 mg may be given
• Duration of Treatment: Usually 5 to 10 days, for chronic prostatitis, cystic fibrosis & chronic Salmonella carriers: 14 days, for endocarditis: Up to 6 months, for chronic osteomyelitis: Up to 1 year, for gonorrhea: 2 tablets single dose

Interaction

Reduced absorption when taken concomitantly with an Antacid containing Aluminium and/or Magnesium Hydroxide gel

Contraindications

• Known hypersensitivity to Quinolone
• Children under 15 years of age
• Pregnant and lactating mothers
• Inborn glucose-6-phosphate dehydrogenase deficiency
• History of tendon lesion, tendonitis or tendon rupture

Side Effects

• Gastrointestinal disturbance
• Central nervous system disturbance
• Hypersensitivity reaction
• Myalgia and/or arthralgia
• Tendonitis
• Rupture of Achilles tendon

Pregnancy & Lactation

Category C by the FDA

Precautions & Warnings

• Risk of photosensitivity reaction
• Avoid exposure to sunlight and ultraviolet radiation
• Dosage readjustment required in severe hepatic insufficiency
• Patients should be informed of the possibility of pain in the Achilles tendon

Therapeutic Class

4-Quinolone preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture, Keep out of the reach of children

Related Brands

• Nobac 400 mg (Tablet) - ibn-sina-pharmaceuticals-ltd