Xenapro Plus 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.00 (5 x 6: ৳ 240.00)

Strip Price: ৳ 48.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	Renata limited
Also available as	Xenapro plus 500 mg tablet

Relief of signs & symptoms of Osteoarthritis
Relief of signs & symptoms of Rheumatoid arthritis
Relief of signs & symptoms of Ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Consists of an immediate release Esomeprazole Magnesium layer & an enteric-coated Naproxen core
Naproxen is a NSAID with analgesic & antipyretic properties
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/k+ -ATPase in the gastric parietal cell

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adults: One tablet twice daily of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
Adolescent Patients 12 Years of Age & Older: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole

Do not split, chew, crush or dissolve the tablet. This tablet is to be taken at least 30 minutes before meals.

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Significantly decrease the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Oedema, hypertension and cardiac failure have been reported in association with NSAID treatment
Peptic ulcers, perforation or GI bleeding, sometimes fatal, particularly in older people, may occur

In women attempting to conceive or during the first and second trimester of pregnancy, Naproxen and Esomeprazole tablet should not be given unless the potential benefit to the patient outweighs the potential risk to the foetus
Naproxen is excreted in low quantities in human milk
The use of NSAIDs like Naproxen may impair female fertility

The combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided
Undesirable effects may be minimized by using the lowest effective dose for the shortest duration necessary to control symptoms
Caution should be advised in patients receiving NSAIDs with concomitant medications which could increase the risk of ulceration or bleeding

Elderly patients: Use caution when high doses are required & some adjustment of dosage may be required
Patients with Moderate to Severe Renal impairment: Not recommended for use in patients with moderate and severe renal impairment
Hepatic insufficiency: Monitor patients with mild to moderate hepatic impairment closely & consider a possible dose reduction

Symptoms related to Naproxen overdose: lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, transient alterations in liver function

Store at temperature of below 30°C, protect from light & moisture. Keep out of reach of children