NapExa 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.00 (7 x 4: ৳ 336.00)
Strip Price: ৳ 48.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Unimed unihealth pharmaceuticals ltd
Also available as
Napexa 500 mg tablet

Indications

  • Relief of Osteoarthritis symptoms
  • Relief of Rheumatoid arthritis symptoms
  • Relief of Ankylosing spondylitis symptoms
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • NSAID with analgesic & antipyretic properties
  • Inhibits prostaglandin synthesis
  • Proton pump inhibitor that suppresses gastric acid secretion

Dosage

  • Consider potential benefits & risks
  • Use lowest effective dose for shortest duration
  • Adult dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole twice daily
  • Adolescent dosage: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole based on weight

Administration

  • Take at least 30 minutes before meals
  • Do not split, chew, crush or dissolve the tablet

Interaction

  • May reduce antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • May increase risk of bleeding complication with warfarin
  • May interfere with absorption of drugs where gastric pH is important
  • Ingestion with high-fat food prolongs absorption & decreases peak plasma concentration

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased incidence of gastrointestinal side effects
  • Lower risk of arterial thrombotic events compared to Naproxen alone
  • Possible adverse events: Oedema, hypertension, cardiac failure, gastrointestinal issues

Pregnancy & Lactation

  • Avoid during first and second trimester of pregnancy
  • Contraindicated during third trimester of pregnancy
  • Not recommended during breastfeeding
  • May impair female fertility

Precautions & Warnings

  • Avoid in combination with other NSAIDs
  • Minimize undesirable effects with lowest effective dose
  • Regular surveillance for long-term treatment patients
  • Increased frequency of adverse reactions in older people
  • Caution in patients with history of gastrointestinal disease, hypertension, and renal impairment

Use in Special Populations

  • Use caution and possible dose adjustment in elderly patients
  • Not recommended in patients with moderate to severe renal impairment
  • Monitor patients with mild to moderate hepatic impairment closely

Overdose Effects

  • Symptoms may include lethargy, dizziness, epigastric pain, and gastrointestinal bleeding
  • Management: Symptomatic and supportive care, with no specific antidotes

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

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