Napronil Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)
Strip Price: ৳ 115.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Pharmasia limited
Also available as
Napronil plus 375 mg tablet

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Gastric ulcers risk reduction

Pharmacology

  • Naproxen & Esomeprazole combination
  • NSAID with analgesic properties
  • Proton pump inhibitor
  • Inhibition of prostaglandin synthesis

Dosage

  • Twice daily dosing
  • Different dose options for adults and adolescents
  • Administration before meals

Administration

  • Do not split, chew, crush or dissolve the tablet
  • Take at least 30 minutes before meals

Interaction

  • Reduced antihypertensive effect with certain drugs
  • Increased bleeding risk with warfarin
  • Interference with drug absorption by Esomeprazole

Contraindications

  • Hypersensitivity to tablet components
  • History of allergic reactions to NSAIDs
  • Contraindicated in peri-operative period for CABG surgery

Side Effects

  • Decrease in gastric ulcers incidence
  • Potential arterial thrombotic events with high doses
  • Gastrointestinal adverse events
  • Oedema, hypertension, cardiac failure reported

Pregnancy & Lactation

  • Caution during conception and early pregnancy
  • Contraindicated in third trimester
  • Not recommended during breastfeeding
  • Potential impact on female fertility

Precautions & Warnings

  • Avoid use with other NSAIDs
  • Use with low dose acetylsalicylic acid
  • Minimize dose and duration for symptom control
  • Special consideration for older patients

Use in Special Populations

  • Caution in elderly patients
  • Not recommended in moderate to severe renal impairment
  • Close monitoring in mild to moderate hepatic impairment

Overdose Effects

  • Symptoms of Naproxen overdose
  • Symptoms of Esomeprazole overdose
  • Symptomatic and supportive care for overdose management

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • NSAIDs

Storage Conditions

  • Store below 30°C
  • Protect from light and moisture
  • Keep out of reach of children

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