Naprozol 375 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 8.03 (5 x 10: ৳ 401.50)

Strip Price: ৳ 80.30

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	General pharmaceuticals ltd
Also available as	Naprozol 500 mg tablet

Relief of signs and symptoms of Osteoarthritis
Relief of signs and symptoms of Rheumatoid arthritis
Relief of signs and symptoms of Ankylosing spondylitis
Decrease in the risk of developing gastric ulcers in patients at risk of NSAID-associated gastric ulcers

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dose: One tablet twice daily of 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole
Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older: 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole for weight greater than 50 kg; 375 mg naproxen/20 mg esomeprazole for weight 38 kg to less than 50 kg

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole inhibits gastric acid secretion & may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
Administration of Naproxen & Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax by 10 hours and decreases peak plasma concentration (Cmax) by about 12%

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthmatic reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Decrease in the occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Gastrointestinal side effects from Naproxen

Avoid combining with other NSAIDs
Minimize undesirable effects by using the lowest effective dose
Risk-factors to develop NSAID related gastro-intestinal complications
Older people have an increased frequency of adverse reactions especially gastro-intestinal bleeding
Patients with a history of GI toxicity should report any unusual abdominal symptoms
Appropriate monitoring and advice required for patients with a history of hypertension and/or mild to moderate congestive heart failure

Use caution and possible dose adjustment in elderly patients
Not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms related to Naproxen overdose: lethargy, dizziness, drowsiness, epigastric pain, abdominal discomfort, heartburn, indigestion, nausea, alterations in liver function
Symptoms related to Esomeprazole overdose: transient
No specific antidotes for Naproxen overdose
No specific antidote known for Esomeprazole overdose