Naprozol 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.03 (5 x 10: ৳ 501.50)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company General pharmaceuticals ltd
Also available as
Naprozol 375 mg tablet

Indications

  • Relief of signs & symptoms of Osteoarthritis
  • Relief of signs & symptoms of Rheumatoid arthritis
  • Relief of signs & symptoms of Ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Consists of immediate release Esomeprazole Magnesium layer & enteric-coated Naproxen core
  • Naproxen: NSAID with analgesic & antipyretic properties
  • Esomeprazole: Proton pump inhibitor that suppresses gastric acid secretion

Dosage

  • Use lowest effective dose for shortest duration consistent with individual patient treatment goals
  • Adult dose: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
  • Adolescent patients 12 years of age & older dose: Based on weight, 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole

Administration

  • Tablet is to be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Concomitant use with warfarin may result in increased risk of bleeding
  • Inhibition of gastric acid secretion & interference with absorption of certain drugs
  • Administration with high-fat food affects absorption of Naproxen

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of asthmay urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
  • Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Possible increased risk of arterial thrombotic events with long-term use
  • Commonly observed adverse events are gastrointestinal in nature, including peptic ulcers, perforation, GI bleeding, nausea, vomiting, diarrhea, etc.

Pregnancy & Lactation

  • Not recommended during first, second, and third trimester of pregnancy
  • Not recommended for use during breastfeeding
  • Use may impair female fertility

Precautions & Warnings

  • Avoid use with other NSAIDs and cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects by using lowest effective dose for shortest duration necessary
  • Consider risk factors for NSAID-related gastro-intestinal complications
  • Increased adverse reactions in older people
  • Consideration for combination therapy with protective agents for high-risk patients
  • Special caution for patients with particular medical conditions

Use in Special Populations

  • Caution and possible dose adjustment in elderly patients
  • Not recommended for use in patients with moderate to severe renal impairment
  • Monitor and consider dose reduction in patients with hepatic insufficiency

Overdose Effects

  • Symptoms and management related to Naproxen and Esomeprazole overdose
  • No known specific antidotes for either component

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C, protect from light & moisture
  • Keep out of reach of children

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