Novaxen Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (28's pack: ৳ 280.00)

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Leon pharmaceuticals ltd
Also available as
Novaxen plus 375 mg tablet

Indications

  • Relief of signs & symptoms of osteoarthritis
  • Relief of signs & symptoms of rheumatoid arthritis
  • Relief of signs & symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Prostaglandin synthesis inhibition by Naproxen
  • Specific inhibition of H+/k+ -ATPase by Esomeprazole

Dosage

  • Use lowest effective dose
  • One tablet twice daily for adults
  • One tablet twice daily for adolescent patients

Administration

  • Tablet is not to be split, chewed, crushed, or dissolved
  • To be taken at least 30 minutes before meals

Interaction

  • Reduced antihypertensive effect of ACE inhibitors, diuretics & beta-blockers with NSAIDs
  • Increased risk of bleeding complication with warfarin
  • Interference with the absorption of certain drugs by Esomeprazole

Contraindications

  • Known hypersensitivity to any tablet component
  • History of asthmay urticaria or allergic reactions to aspirin or other NSAIDs
  • Use during peri-operative period in coronary artery bypass graft (CABG) surgery

Side Effects

  • Decreased occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Increased risk of arterial thrombotic events at high doses
  • Gastrointestinal adverse events
  • Oedema, hypertension and cardiac failure

Pregnancy & Lactation

  • Avoid use during first and second trimester of pregnancy
  • Contraindicated during third trimester of pregnancy
  • Avoid use during breastfeeding
  • Impaired female fertility with NSAID use

Precautions & Warnings

  • Avoid combination with other NSAIDs
  • Minimize undesirable effects by using lowest effective dose
  • Regular surveillance for long-term treatment
  • Increased frequency of adverse reactions in older people

Use in Special Populations

  • Increased unbound plasma fraction of naproxen in elderly
  • Not recommended for patients with moderate to severe renal impairment
  • Close monitoring in patients with mild to moderate hepatic impairment

Overdose Effects

  • Symptoms related to Naproxen overdose
  • Symptoms related to Esomeprazole overdose
  • Symptomatic and supportive care for NSAID overdose
  • No specific antidote for Esomeprazole overdose

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • NSAIDs

Storage Conditions

  • Store below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Related Brands