Peflox 400 mg (Tablet)
Unit Price: ৳ 12.00 (2 x 10: ৳ 240.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pefloxacin mesylate dihydrate |
| Company | Drug international ltd |
Indications
- Gastrointestinal infection
- Urinary tract infection
- Respiratory tract infection
- Ear, nose and throat infection
- Bone and joint infection
- Skin and soft tissue infection
- Pelvic infection
- Abdominal and hepatobiliary infection
- Septicemia
- Bacteraemia
- Gonorrhoea
- Endocarditis
- Meningitis
Pharmacology
Synthetic antibacterial agent, belongs to fluoroquinolone group. Inhibits the subunit-A of DNA gyrase (Topoisomerase II). Bactericidal and has a broad spectrum of activity.
Dosage & Administration
- Adult with normal hepatic function: 400 mg tablet 12 hourly with meals
- An initial loading dose of 800 mg may be given
- Adult with hepatic insufficiency: readjusted doses by increasing intervals
- Duration of Treatment: Usually 5 to 10 days, chronic prostatitis, cystic fibrosis & chronic Salmonella carriers: 14 days, endocarditis: Up to 6 months, chronic osteomyelitis: Up to 1 year, gonorrhoea: 2 tablets single dose.
Interaction
Absorption reduced when taken concomitantly with an Antacid containing Aluminium and/or Magnesium Hydroxide gel.
Contraindications
- Known hypersensitivity to Quinolone
- Children under 15 years of age
- Pregnant and lactating mothers
- Inborn glucose-6-phosphate dehydrogenase deficiency
- History of tendon lesion, tendonitis or tendon rupture
Side Effects
- Gastrointestinal disturbance: Epigastric pain, nausea, vomiting, diarrhoea, dyspepsia
- Central nervous system disturbance: Headache, insomnia
- Hypersensitivity reaction: Skin rash, pruritis, photosensitization
- Others: Myalgia and/or arthralgia, tendonitis, rupture of achilles tendon
Pregnancy & Lactation
Assigned to pregnancy category C by the FDA.
Precautions & Warnings
Risk of photosensitivity reaction, exposure to sunlight and ultraviolet radiation should be avoided. Dosage readjustment is required in severe hepatic insufficiency. Patients should be informed of the possibility of pain in the achilles tendon.
Therapeutic Class
4-Quinolone preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.