Tenoflex 20 mg (Tablet)
Unit Price: ৳ 8.05 (3 x 10: ৳ 241.50)
Strip Price: ৳ 80.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Tenoxicam |
| Company | Beacon pharmaceuticals plc |
Indications
- Symptomatic treatment of rheumatoid arthritis
- Treatment of osteoarthritis
- Management of arthrosis
- Symptomatic relief for ankylosing spondylitis
- Relief of tendinitis and bursitis
- Pain management for strains and sprains
- Treatment of acute gout
Pharmacology
- Non-steroidal anti-inflammatory drug (NSAID)
- Anti-inflammatory properties
- Analgesic properties
- Antipyretic properties
- Platelet aggregation inhibitor
- Inhibition of prostaglandin biosynthesis
- Inhibition of leukocyte peroxidase
- Inhibition of metalloproteinases
- Scavenging action for active oxygen
- No mutagenic, carcinogenic, or teratogenic effects
Dosage
- Standard dosage of 20 mg daily
- Higher dosage for acute gout initially
- Progressive increase in response over time in chronic disorders
- Avoidance of daily doses higher than 20 mg in chronic disorders
- Special dosage instructions for elderly and patients with kidney or liver disease
- No established dosage recommendations for children and adolescents
Administration
- Tablets to be taken with a glass of water
- Preferable to take with or after a meal
Interaction
- Salicylate displacement and increased clearance
- Concurrent treatment with salicylate or other NSAIDs should be avoided
- Caution with concurrent methotrexate administration
- Potential decrease in renal clearance and increased plasma levels of lithium
- Avoid concurrent administration with K-sparing diuretics
- Attenuation of blood pressure-lowering effect of hydrochlorothiazide
- Potential attenuation of antihypertensive effects of alpha-adrenergic blockers and ACE-inhibitors
Contraindications
- Hypersensitivity to the drug
- Induction of asthma, rhinitis, or urticaria by salicylates or other NSAIDs
- History of upper gastrointestinal tract diseases
Side Effects
- Gastrointestinal discomfort, dyspepsia, heartburn, nausea
- Dizziness, headache
- Constipation, diarrhea, stomatitis, gastritis, vomiting, ulcers
- Fatigue, sleep disturbances, dry mouth, vertigo
- Skin itching, erythema, rash, urticaria
- Increase in BUN or creatinine, edema
- Elevated liver enzyme activity
- Palpitations, visual disturbances, photosensitivity reaction
- Anemia, agranulocytosis, leukopenia, thrombocytopenia
- Hypersensitivity reactions, elevated blood pressure, hepatitis
Pregnancy & Lactation
- Avoidance of treatment during the third trimester of pregnancy
- Passage of a very small amount into breast milk
- No evidence of adverse reactions in breast-fed infants
Precautions & Warnings
- Inhibition of renal prostaglandin synthesis and potential undesirable effects on renal hemodynamics
- Inhibition of platelet aggregation and potential impact on hemostasis
- Careful monitoring for gastrointestinal disease and skin reactions
- Caution with patients with coagulation disorders or receiving drug therapy that interferes with hemostasis
- Ophthalmic evaluation for patients with visual disturbances
- Caution required when plasma albumin levels are markedly reduced
Use in Special Populations
- Not recommended for use in patients under 16 years of age
- Potential adverse events affecting ability to drive or use machines
Overdose Effects
- Expectation of more pronounced undesirable effects
- Recommendation for conventional measures to reduce absorption and speed up elimination
Therapeutic Class
- Drugs for osteoarthritis
- Drugs used for rheumatoid arthritis
- Non-steroidal anti-inflammatory drugs (NSAIDs)
Storage Conditions
- Do not store above 30°C
- Protection from light and moisture
- Keep out of the reach of children