Raditil 20 mg (Tablet)
Unit Price: ৳ 18.00 (5 x 10: ৳ 900.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tenoxicam |
| Company | Radiant pharmaceuticals ltd |
Indications
- Symptomatic treatment for rheumatoid arthritis
- Symptomatic treatment for osteoarthritis
- Symptomatic treatment for arthrosis
- Symptomatic treatment for ankylosing spondylitis
- Symptomatic treatment for tendinitis
- Symptomatic treatment for bursitis
- Symptomatic treatment for periarthritis of the shoulders
- Symptomatic treatment for strains
- Symptomatic treatment for sprains
- Symptomatic treatment for acute gout
Pharmacology
- Non-steroidal anti-inflammatory drug
- Anti-inflammatory properties
- Analgesic properties
- Antipyretic properties
- Platelet aggregation inhibition
- Prostaglandin biosynthesis inhibition
- Leukocyte peroxidase scavenging
- Inhibitor of metalloproteinases
- No mutagenic effects
- No carcinogenic effects
- No teratogenic effects
Dosage
- Standard daily dosage of 20mg
- 40mg dosage for acute gout attacks
- Therapeutic effect evident early in treatment
- Progressive increase in response over time
- Avoid daily doses higher than 20mg for chronic disorders
- Reduction to a daily oral dose of 10mg for long-term treatment
- Applicable to elderly and patients with kidney or liver disease
- No established dosage recommendations for children and adolescents
Administration
- Tablets to be taken with a glass of water
- Preferable to take medicine during or immediately after a meal
Interaction
- Salicylate displacement from protein-binding sites
- Increased clearance and volume of distribution with salicylate
- Avoid concurrent treatment with salicylate or other NSAIDs
- Caution with concurrent administration of methotrexate
- Do not administer concurrently with K-sparing diuretics
- Interaction with lithium leading to increased plasma levels
- Attenuation of blood pressure-lowering effect of hydrochlorothiazide
- Attenuation of antihypertensive effects with alpha-adrenergic blockers and ACE-inhibitors
- No interactions reported with centrally-acting alpha agonists or calcium channel blockers
- No clinically relevant interaction with atenolol
- No interaction with concomitantly administered antacids, cimetidine, warfarin, phenprocoumon, and low molecular weight heparin
Contraindications
- Hypersensitivity to the drug
- Hypersensitivity to salicylates or other NSAIDs inducing asthma, rhinitis, or urticaria
- Disease of the upper gastrointestinal tract such as gastritis, gastric and duodenal ulcer
Side Effects
- Gastrointestinal discomfort
- Dyspepsia
- Headache
- Constipation
- Diarrhea
- Stomatitis
- Gastritis
- Vomiting
- Ulcers
- Gastrointestinal bleeding
- Fatigue
- Sleep disturbances
- Skin itching and rash
- Urinary tract and kidney effects
- Increased liver enzyme activity
- Cardiovascular effects
- Visual disturbances
- Anemia
- Leukopenia
- Thrombocytopenia
- Hypersensitivity reactions
- Elevated blood pressure
- Hepatitis
Pregnancy & Lactation
- Inhibitory effect on prostaglandin synthesis during late pregnancy
- Avoid treatment during the third trimester of pregnancy
- Small amount passing into breast milk
- No evidence of adverse reactions in breast-fed infants
- Weaning or discontinuation recommended
Precautions & Warnings
- Inhibition of renal prostaglandin synthesis
- Elevated risk of renal failure in certain conditions
- Inhibition of platelet aggregation
- No significant influence on blood coagulation factors
- Necessity to monitor patients with coagulation disorders or receiving drug therapy that interferes with hemostasis
- Close monitoring of patients presenting with gastrointestinal disease
- Immediate withdrawal if peptic ulceration or gastrointestinal bleeding occurs
- Discontinuation if severe skin reactions occur
- Ophthalmic evaluation recommended for patients with visual disturbances
- Caution required when plasma albumin levels are reduced
- Masking of usual signs of infection
- Avoidance in patients who dislike or do not tolerate milk products
Use in Special Populations
- Not recommended for use in patients under 16 years of age
- Effects on ability to drive and use machines in patients experiencing adverse events
Overdose Effects
- Expected exacerbation of undesirable effects
- Counter measures to reduce absorption and speed up elimination
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Do not store above 30°C
- Protect from light and moisture
- Keep out of the reach of children