Arain 200 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Opsonin pharma ltd |
Product Title
- Arain 200 mg Tablet
Categories
- Pain Relief
- Fever Management
- Migraine Treatment
- NSAIDs
Description
- Potent inhibitor of cyclooxygenase enzyme
- Inhibits synthesis of inflammatory mediators like thromboxane B2 and prostaglandin E2
- Relieves migraine headache pain
- Analgesic for post-operative pain
- Fenamate group member with direct antagonistic action on prostaglandin receptors
- Readily absorbed from GI tract
- Peak plasma concentration: 60-90 min
- Bioavailability: 85%
- Protein-binding: 99%
- Plasma half-life: 2 hours
- Metabolized in the liver
- Undergoes enterohepatic circulation
- Excreted in urine (90%) and feces
- Dosage: 200 mg for acute migraine attacks
- Dosage: 100-200 mg for mild to moderate pain, three times a day
- Dosage adjustments may be needed for renal impairment
- Avoid in severe renal impairment
- Not established for pediatric dosage regimen
- Take with food and water during or immediately after meals
- Increases absorption with Metoclopramide and Magnesium hydroxide
- Decreases absorption with Aluminium hydroxide
- Increases bleeding risk with anticoagulants and other NSAIDs
- Decreases antihypertensive response to loop diuretics, B-blockers, and ACE inhibitors
- Increases plasma concentration of Lithium, Methotrexate, and cardiac glycosides
- Increases risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
- Contraindications: active gastrointestinal bleeding and ulceration, severe heart failure
- Side Effects: alveolitis, hepatic damage, pancreatitis, pulmonary eosinophilia, Stevens-Johnson syndrome, angioedema, blood disorder, depression, diarrhea, dizziness, drowsiness, dysuria, euphoria, gastrointestinal bleeding, discomfort, hallucination, insomnia, malaise, nausea, hearing and visual disturbances, vertigo, raised blood pressure, headache, vomiting, convulsion, acute renal failure, and liver damage in case of significant poisoning
- Not recommended during pregnancy, especially in the third trimester
- NSAIDs can appear in breast milk in very low concentrations
- Precautions for patients with asthma, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment, and elderly
- Increase water intake or dose reduction to reduce dysuria
- Symptomatic treatment for overdose effects
- Therapeutic Class: Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs), Other drugs for migraine
- Store in a cool, dry place, away from light, keep out of the reach of children
- Molecular Formula: C14H12ClNO2