Namitol 200 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Aci limited |
Indications
- Relieving migraine headache
- Analgesic in post-operative pain and fever
Pharmacology
- Belongs to fenamate group
- Inhibits cyclooxygenase enzyme
- Inhibits synthesis of inflammatory mediators
- Has direct antagonistic action on prostaglandin receptors
- Absorbed readily from GI tract
- Peak plasma concentration: 60-90 min
- Bioavailability: 85%
- Plasma half-life: 2 hours
- Metabolized in the liver
- Excreted in urine and feces
Dosage & administration
- Adult dosage for acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
- Adult dosage for mild to moderate pain: 100-200 mg tid
- Dose adjustment may be needed for renal impairment
- Avoid in severe renal impairment
- Pediatric dosage regimen not established
Interaction
- Rate of absorption increases with Metoclopramide and Magnesium hydroxide
- Rate of absorption decreases with Aluminium hydroxide
- Increases risk of bleeding with anticoagulants and other NSAIDs
- Decreases antihypertensive response to loop diuretics, B-blockers, and ACE Inhibitors
- Increases plasma concentration of Lithium, Methotrexate, and cardiac glycosides
- Increases risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
Contraindications
- Active gastrointestinal bleeding
- Active gastrointestinal ulceration
- History of gastrointestinal bleeding related to previous NSAID therapy
- Severe heart failure
Side effects
- Rare alveolitis
- Hepatic damage
- Pancreatitis
- Pulmonary eosinophilia
- Stevens-johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastrointestinal bleeding
- Hallucination
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Raised blood pressure
- Symptoms of overdose: Headache, nausea, vomiting, gastrointestinal bleeding, drowsiness, dizziness, convulsion, acute renal failure, liver damage
Pregnancy & lactation
- Not recommended during pregnancy unless considered essential by doctor
- Not recommended during the third trimester
- NSAIDs can appear in breast milk in low concentrations
- NSAIDs should be avoided if possible when breastfeeding
Precautions & warnings
- Precautions for patients with asthma, bronchospasm, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment, and elderly
- Increase water intake or dose reduction to reduce dysuria
Overdose effects
- Symptoms of overdose: Headache, nausea, vomiting, epigastric pain, diarrhea, excitation, coma, drowsiness, tinnitus, fainting, convulsions
- Possible acute renal failure and liver damage
- Patients should be treated symptomatically as required
Therapeutic class
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Other drugs for migraine
Storage conditions
- Store in a cool and dry place, away from light
- Keep out of the reach of children
Chemical structure
- Molecular Formula: C14H12ClNO2
- Chemical Image URL: https://medex.com.bd/storage/res/g-res-1092-tolfenamic-acid-chemical-structure-dzPweN5r9IE4mD1xFrIL.svg
Common questions about namitol 200 mg tablet
- Potent inhibitor of cyclooxygenase enzyme
- Used for the treatment of acute migraine attacks and mild to moderate pain
- Should be taken with food or milk to avoid getting an upset stomach
- Can cause serious complications if taken for a long time
Chemical structure
- Molecular Formula: C14H12ClNO2
- Chemical Image URL: https://medex.com.bd/storage/res/g-res-1092-tolfenamic-acid-chemical-structure-dzPweN5r9IE4mD1xFrIL.svg