Tolmic 200 mg (Tablet)
Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)
Strip Price: ৳ 80.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Beximco pharmaceuticals ltd |
Indications
- Relieves migraine headache pain
- Analgesic for post-operative pain
- Analgesic for fever
Pharmacology
- Belongs to fenamate group
- Inhibitor of cyclooxygenase enzyme
- Inhibits synthesis of inflammatory mediators
- Acts on prostaglandin synthesis
- Direct antagonistic action on prostaglandin receptors
- Readily absorbed from GI tract
- Peak plasma concentration: 60-90 min
- Bioavailability: 85%
- Metabolized in the liver
- Excreted in urine and feces
Dosage & Administration
- 200 mg for acute migraine attacks
- 100-200 mg for mild to moderate pain
- Dose adjustment for renal impairment
- Not recommended for severe renal impairment
- Take with food
- Take with water during or immediately after meals
Interaction
- Increased absorption with Metoclopramide and Magnesium hydroxide
- Decreased absorption with Aluminium hydroxide
- Increased risk of bleeding with anticoagulants and other NSAIDs
- Decreased antihypertensive response to loop diuretics, B-blockers, and ACE Inhibitors
- Increased plasma concentration of Lithium, Methotrexate, and cardiac glycosides
- Increased risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus, or diuretics
Contraindications
- Active gastrointestinal bleeding or ulceration
- History of gastrointestinal bleeding related to previous NSAID therapy
- History of gastrointestinal haemorrhage or perforation related to previous NSAID therapy
- History of recurrent gastrointestinal ulceration
- Severe heart failure
Side Effects
- Rare alveolitis
- Hepatic damage
- Pancreatitis
- Pulmonary eosinophilia
- Stevens-johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastrointestinal bleeding and discomfort
- Hallucinations
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Raised blood pressure
- Symptoms of overdose: headache, nausea, vomiting, gastrointestinal bleeding, drowsiness, dizziness, convulsions, acute renal failure, and liver damage
Pregnancy & Lactation
- Not recommended during pregnancy unless essential
- Avoid during third trimester of pregnancy
- NSAIDs can appear in breast milk in very low concentrations
Precautions & Warnings
- Patients with asthma bronchospasm
- Patients with bleeding disorders
- Patients with cardiovascular diseases
- Patients with peptic ulceration
- Patients with hypertension
- Patients with liver infection
- Patients with cardiac or renal function impairment
- Elderly patients
- Increased water intake or dose reduction for reduced dysuria
Overdose Effects
- Symptoms: headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, excitation, coma, drowsiness, dizziness, tinnitus, fainting, convulsions, acute renal failure, and liver damage
- Treatment should be symptomatic as required
Therapeutic Class
- Rheumatoid Arthritis drugs
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Migraine medications
Storage Conditions
- Store in a cool and dry place away from light
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C14H12ClNO2
- Chemical Structure Image: [Link to image]
Common Questions about Tolmic 200 mg Tablet
- Potent inhibitor of cyclooxygenase enzyme
- Used for the treatment of acute migraine attacks and mild to moderate pain
- Should be taken with food or milk to avoid an upset stomach
- Can cause serious complications like stomach bleeding and kidney problems if taken for a long time
- Can raise the risk of blood clots, heart attack, or stroke
- Should be avoided during the third trimester of pregnancy
- NSAIDs should, if possible, be avoided when breastfeeding
- Inform the doctor about pregnancy, planning to conceive, breastfeeding, kidney problems, or liver problems