Tufnil 200 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Eskayef pharmaceuticals ltd |
Title
Tufnil 200 mg Tablet
Categories
- Pain Relief
- Migraine Relief
- Fever Relief
- Analgesic
Description
Tufnil 200 mg Tablet is a potent inhibitor of cyclooxygenase enzyme, thus it inhibits the synthesis of important inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2. It is used for the treatment of acute migraine attacks, mild to moderate pain, and post-operative pain and fever. Tolfenamic acid belongs to the fenamate group and is a potent inhibitor of cyclooxygenase enzyme. It acts not only by inhibiting prostaglandin synthesis, but it also has direct antagonistic action on its receptors. Tufnil increases the rate of absorption with Metoclopramide and Magnesium hydroxide but decreases with Aluminium hydroxide. It also has interactions with anticoagulants, NSAIDs, loop diuretics, B-blockers, ACE Inhibitors, Lithium Methotrexate, cardiac glycosides, ACE inhibitors, Ciclosporin, Tacrolimus, and diuretics. It is contraindicated in cases of active gastro-intestinal bleeding, ulceration, heart failure, and history of gastro-intestinal issues related to NSAID therapy. Side effects include rare alveolitis, hepatic damage, pancreatitis, pulmonary eosinophilia, Stevens-johnson syndrome, angioedema, blood disorder, depression, diarrhea, dizziness, drowsiness, dysuria, euphoria, gastrointestinal bleeding, discomfort, hallucination, insomnia, malaise, nausea, hearing disturbances, rash, visual disturbances, vertigo, raised blood pressure. Tufnil is not recommended during pregnancy and should be avoided during breastfeeding. Precautions should be taken for patients with asthma, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, and renal function impairment. Storage conditions require it to be kept in a cool and dry place, away from light and out of the reach of children.
Attributes
- Indications:
- Relieving migraine headache
- Analgesic in post-operative pain and fever
- Pharmacology:
- Potent inhibitor of cyclooxygenase enzyme
- Inhibits synthesis of inflammatory mediators
- Direct antagonistic action on prostaglandin receptors
- Dosage & Administration:
- 200 mg for acute migraine attacks
- 100-200 mg for mild to moderate pain
- Dose adjustments for renal impairment
- Take with food and water
- Interactions:
- Increased absorption rate with Metoclopramide and Magnesium hydroxide
- Decreased absorption with Aluminium hydroxide
- Interactions with anticoagulants, NSAIDs, diuretics, Lithium, Methotrexate, cardiac glycosides, ACE inhibitors, Ciclosporin, Tacrolimus
- Contraindications:
- Active gastro-intestinal bleeding
- Severe heart failure
- History of gastro-intestinal issues related to NSAID therapy
- Side Effects:
- Alveolitis
- Hepatic damage
- Pulmonary eosinophilia
- Stevens-johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastrointestinal bleeding
- Hallucination
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Raised blood pressure
- Acute overdose effects
- Pregnancy & Lactation:
- Not recommended during pregnancy
- Avoid during breastfeeding
- NSAIDs can appear in breast milk
- Precautions & Warnings:
- Patients with asthma and bronchospasm
- Patients with bleeding disorders
- Patients with cardiovascular diseases
- Patients with peptic ulceration
- Patients with hypertension
- Patients with liver infection
- Patients with renal function impairment
- Elderly patients
- Dose reduction for dysuria reduction
- Increased water intake
- Overdose Effects:
- Headache
- Nausea
- Vomiting
- Epigastric pain
- Gastrointestinal bleeding
- Diarrhea
- Excitation
- Coma
- Drowsiness
- Dizziness
- Tinnitus
- Fainting
- Convulsions
- Acute renal failure
- Liver damage
- Symptomatic treatment
- Therapeutic Class:
- Rheumatoid Arthritis Drugs
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Migraine Relief Drugs
- Storage Conditions:
- Cool and dry place
- Away from light
- Keep out of reach of children