Misoclo 50 mg+200 mcg (Tablet)

Unit Price: ৳ 10.07 (2 x 10: ৳ 201.40)
Strip Price: ৳ 100.70

Medicine Details

Category Details
Generic Diclofenac sodium misoprostol
Company General pharmaceuticals ltd
Also available as
Misoclo 75 mg tablet

Product Title

  • Misoclo

Categories

  • Medicines
  • Pain Relief
  • Arthritis Treatment

Description

  • Misoclo is indicated for treatment of the signs and symptoms of osteoarthritis or rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications. It is a combination product containing Diclofenac Sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and Misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E 1 analog.

Indications

  • Treatment of osteoarthritis
  • Treatment of rheumatoid arthritis
  • High risk of NSAID-induced gastric and duodenal ulcers

Pharmacology

  • Mechanism of action related to prostaglandin synthetase inhibition
  • Prostaglandin synthesis inhibition
  • Increased bicarbonate and mucous production
  • Prevention of gastric and duodenal ulcers

Dosage and Administration

  • Recommended dosage for maximal GI mucosal protection for osteoarthritis and rheumatoid arthritis
  • Alternative dosages for patients experiencing intolerance

Interaction

  • Concomitant administration with aspirin not recommended
  • Elevated digoxin levels reported
  • Synergistic effects with warfarin on GI bleeding
  • Effects on glucose metabolism
  • Antacids reducing bioavailability
  • Inhibition of diuretic activity

Contraindications

  • Hypersensitivity to Diclofenac, Misoprostol, or other prostaglandins
  • History of asthma, urticaria, or allergic-type reactions to aspirin or other NSAIDs

Side Effects

  • Common reported side effects: abdominal pain, diarrhea, and other GI symptoms
  • Rare instances of profound diarrhea leading to severe dehydration

Pregnancy and Lactation

  • Contraindicated in pregnant women due to abortifacient property of Misoprostol
  • Diclofenac Sodium found in the milk of nursing mothers
  • Not recommended for use by nursing mothers

Precautions and Warnings

  • Careful monitoring in patients with underlying conditions or dehydration

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety or effectiveness observed in geriatric use
  • Greater sensitivity of some elderly persons cannot be ruled out

Overdose Effects

  • Misoprostol overdose effects: convulsions, sedation, tremor, dyspnoea, diarrhea, abdominal pain, fever, palpitations, hypotension, bradycardia
  • Diclofenac overdose effects: lethargy, drowsiness, nausea, vomiting, GI bleeding, HTN, acute renal failure, respiratory depression, anaphylactoid reactions, coma

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store in a cool and dry place below 25°C
  • Protect from light

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