Avas 40 mg (Tablet)
Unit Price: ৳ 28.00 (1 x 14: ৳ 392.00)
Strip Price: ৳ 392.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Reduce total cholesterol and LDL cholesterol in patients with familial hypercholesterolaemia
- Treat mixed dyslipidemia and hypertriglyceridemia
- Reduce serum triglyceride levels in hypertriglyceridaemia
- Treat dysbetalipoproteinaemia
- Reduce cardiac ischaemic events in patients with coronary artery disease
- Lower cholesterol levels in patients with diabetes mellitus or renal transplantation
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Inhibits cholesterol synthesis in the liver
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
- Rapidly absorbed after oral administration
- Metabolized to ortho- and parahydroxylated derivatives
Dosage & Administration
- Adults dosage range: 10-80 mg once daily
- Child dosage range: 10-20 mg once daily
- Initial dose for familial hypercholesterolaemia: 10 mg daily
- Maximum dose for hypercholesterolaemia: 80 mg once daily
Interaction
- Increased risk of myopathy with cyclosporine
- Plasma concentrations decrease when coadministered with antacid
- Plasma concentrations decrease when coadministered with colestipol
- Steady-state plasma digoxin concentrations increase with digoxin coadministration
- Increased plasma concentrations with erythromycin
- Increased AUC values for oral contraceptives
Contraindications
- Hypersensitivity to any component
- Active liver disease
- History of serious adverse reaction to HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not recommended during breastfeeding
- No studies on excretion in human milk
Precautions & Warnings
- Liver function tests before initiation of treatment
- Caution in patients with alcohol consumption or liver disease
- Discontinue therapy if markedly elevated CPK levels occur
Use in Special Populations
- Higher plasma concentrations in healthy elderly subjects
- No clinically significant difference in LDL reduction between men and women
- No dose adjustment needed in renal dysfunction
- Markedly increased concentrations in chronic alcoholic liver disease
Overdose Effects
- Specific treatment not available
- Symptomatic treatment suggested
- Liver function tests and serum CK levels monitoring recommended
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
Common Questions about Avas 40 mg Tablet
- Used for heart attacks and hypercholesterolaemia
- Instructions for storage and disposal provided
- No significant difference in LDL-C reduction between men and women
- Monitor liver function and signs of liver problems
- Caution advised in renal dysfunction