Actemra 80 mg/4 ml (IV Infusion)

4 ml vial: ৳ 9,848.40

Medicine Details

Category Details
Generic Tocilizumab
Company Roche bangladesh ltd
Also available as
Actemra 200 mg injection Actemra 162 mg injection Actemra 400 mg injection

Title

  • Actemra (Tocilizumab)

Categories

  • Medicine
  • Biologics
  • Immunosuppressants

Description

  • Interleukin-6 (IL-6) receptor antagonist indicated for treatment of various conditions including Rheumatoid Arthritis, Polyarticular Juvenile Idiopathic Arthritis, Systemic Juvenile Idiopathic Arthritis, COVID-19, Cytokine Release Syndrome, Giant Cell Arteritis, and Systemic Sclerosis-Associated Interstitial Lung Disease.

Color Options

  • N/A

Dimensions

  • N/A

Functions

  • Inhibition of IL-6-mediated signaling
  • Reduction of inflammation and immune response

Materials

  • Recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody
  • Immunoglobulin IgG1K subclass

Technical Specifications

  • Dosage varies based on condition and patient weight
  • Intravenous and subcutaneous administration
  • Storage temperature: 2°C to 8°C
  • Caution in coadministration with CYP3A4 substrate drugs

Design Elements

  • Recombinant protein
  • Monoclonal antibody

Usability Features

  • Treatment of adults and pediatric patients

Dosage & Administration

  • Intravenous infusion or subcutaneous injection
  • Dosage regimen based on weight and clinical response
  • Interruption of dosing for dose-related laboratory abnormalities

Interaction

  • Exercise caution when coadministering with CYP3A4 substrate drugs

Contraindications

  • Known hypersensitivity to Tocilizumab

Side Effects

  • Common adverse reactions: upper respiratory tract infections, headache, hypertension, increased ALT, injection site reactions
  • COVID-19 specific adverse reactions: constipation, anxiety, diarrhea, insomnia, hypertension, nausea

Pregnancy & Lactation

  • May cause fetal harm based on animal data
  • Use during pregnancy only if potential benefit justifies potential risk

Precautions & Warnings

  • Do not administer during active infection
  • Evaluation for tuberculosis risk factors prior to initiation
  • Monitor for signs and symptoms of hepatic injury
  • Hypersensitivity reactions reported

Use in Special Populations

  • Safety and effectiveness not established in certain pediatric and geriatric populations
  • No dose adjustment required in mild or moderate renal impairment

Overdose Effects

  • Monitor for signs and symptoms of adverse reactions in case of overdose
  • Provide appropriate symptomatic treatment for adverse reactions

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis

Storage Conditions

  • Store at 2°C to 8°C, do not freeze

Related Brands