Febus 40 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Febuxostat |
| Company | Aci limited |
| Also available as |
Indications
- Chronic management of hyperuricemia in patients with gout
- Not recommended for the treatment of asymptomatic hyperuricemia
Pharmacology
- Non-purine, selective xanthine oxidase (XO) inhibitor
- Decreases serum uric acid level by inhibiting xanthine oxidase
- Not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations
Dosage & Administration
- Recommended starting dose of Febuxostat 40 mg tablet once daily
- Dosage adjustment based on serum uric acid levels
- Recommended dose for Tumor Lysis Syndrome and Gout Flares
- No dose adjustment needed for renal or hepatic impairment
- Safety and effectiveness in pediatric patients under 18 years of age not established
Interaction
- Contraindicated with mercaptopurine/azathioprine/theophylline
- No dose adjustment required for co-administration with rosiglitazone/CYP2C8 substrates, naproxen, colchicine, indomethacin, hydrochlorothiazide, warfarin, antacids
- Monitoring recommended for inducers of glucuronidation
Contraindications
- Contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline
Side Effects
- Common adverse reactions include gout flares, liver function abnormalities, diarrhea, nausea, headache, rash, and edema
- Rare serious hypersensitivity reactions observed
Pregnancy & Lactation
- Pregnancy Category C
- Caution advised during lactation
Precautions & Warnings
- Increased gout flares during initiation of treatment
- Higher rate of cardiovascular thromboembolic events observed
- Transaminase elevations observed in treated patients
- Monitor for signs and symptoms of MI and stroke
Overdose Effects
- Studied in healthy subjects in doses up to 300 mg daily for seven days without evidence of dose-limiting toxicities
Therapeutic Class
- Drugs used in Gout
Storage Conditions
- Keep below 30°C temperature
- Keep away from light & moisture
- Keep out of the reach of children