Avator 10 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Reduction of elevated total cholesterol levels
- Reduction of LDL cholesterol levels
- Reduction of apolipoprotein B levels
- Reduction of triglycerides levels
- Treatment of heterozygous and homozygous familial hypercholesterolaemia
- Treatment of mixed dyslipidemia
- Treatment of hypertriglyceridaemia
- Treatment of dysbetalipoproteinaemia
- Reduction of cardiac ischaemic events
- Reduction of cholesterol concentrations associated with diabetes mellitus or renal transplantation
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
- Rapid absorption after oral administration
- Metabolized to ortho- and parahydroxylated derivatives and beta-oxidation products
- Extensively metabolized by cytochrome P450 3A4
- Eliminated primarily in bile
- Mean plasma elimination half-life of approximately 14 hours
Dosage & Administration
- Adult dosage: 10-80 mg once daily
- Child (10-18 years) dosage: 10-20 mg once daily
- Initial dosage of 10 mg daily for familial hypercholesterolaemia
- Dosage adjustment according to lipid levels
Interaction
- Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, and azole antifungals
- Altered plasma concentrations when coadministered with antacids, colestipol, digoxin, erythromycin, and oral contraceptives
- No clinically significant effect on prothrombin time when coadministered with warfarin
Contraindications
- Hypersensitivity to any component of the medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- No established safety in pregnant women
- Potential reduction of fetal levels of mevalonate
- Not known whether excreted in human milk
- Contraindicated during breastfeeding
Precautions & Warnings
- Liver function tests before initiation of treatment and periodically thereafter
- Discontinue if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
Use in Special Populations
- Higher plasma concentrations in healthy elderly subjects
- Greater degree of LDL-lowering in the elderly patient population
- No clinically significant difference in LDL-C reduction between men and women
- No influence on plasma concentrations or LDL-C reduction in renal disease
Overdose Effects
- No specific treatment available
- Symptomatic treatment and supportive measures
- Monitoring of liver function tests and serum CK levels
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5