Baclium 10 mg (Tablet)

Unit Price: ৳ 8.00 (30's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Baclofen
Company Virgo pharmaceuticals ltd

Indications

  • spasticity resulting from multiple sclerosis
  • flexor spasms and concomitant pain, clonus and muscular rigidity
  • skeletal muscle spasm resulting from rheumatic disorders
  • spinal cord injuries and other spinal cord diseases
  • cerebrovascular accidents or neoplastic or degenerative brain disease

Pharmacology

Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.

Dosage & Administration

  • Adult & children over 10 years: 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily
  • Children <10 years: Treatment is usually started with 2.5 mg (2.5 ml) given 4 times daily then raised according to requirement. Daily maintenance dose- 12 month-2 years: 10-20 mg (10-20 ml), 2 years-6 years: 20-30 mg (20-30 ml), 6 years-10 years: 30-60 mg (30-60 ml)

Interaction

  • Increased sedation may occur if Baclium is taken with agents acting on the central nervous system, alcohol or synthetic opiates. The risk of respiratory depression is also increased.
  • Combined treatment with Baclium and antihypertensives is likely to increase the fall in blood pressure; therefore the dosage of antihypertensive medication should be adjusted accordingly.
  • The concomitant administration of Baclium and tricyclic antidepressants may potentiate the pharmacological effects of Baclium resulting in pronounced muscular hypotonia.

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

Side Effects

  • Central Nervous System:
    • Headache (<10%)
    • insomnia (<10%)
    • euphoria
    • excitement
    • depression
    • confusion
    • hallucinations
  • Cardiovascular: Hypotension (<10%), rare instances of dyspnoea, palpitation, chest pain, syncope
  • Gastrointestinal:
    • Nausea (approximately 10%)
    • constipation (<10%) and rarely, dry mouth, anorexia, taste disorder
  • Genitourinary:
    • Urinary frequency (<10%) and rarely, enuresis, urinary retention, dysuria, impotence
  • Other:
    • rash
    • pruritus
    • ankle edema
    • excessive perspiration
    • weight gain
    • visual disturbances
    • hepatic function disorders

Pregnancy & Lactation

Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established.

Precautions & Warnings

  • Lower doses (approximately 5 mg per day) should be used for patients with impaired renal function
  • Patients suffering not only from spasticity but also from psychotic disorders should be treated cautiously and closely monitored

Overdose Effects

Gastric lavage is important in case of severe overdose.

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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