Fenobac 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain, clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.
Dosage & Administration
- 5 mg 3 times daily, preferably with or after food, gradually increased; max. 100 mg daily
- Treatment for children under 10 years
Interaction
- Sedation potential when taken with CNS agents, alcohol or synthetic opiates
- Increased fall in blood pressure when combined with antihypertensives
- Potentiated effects when taken with tricyclic antidepressants
- Reports of mental confusion, hallucinations, headaches, nausea and agitation in patients with Parkinson's disease receiving treatment with Baclofen and levodopa and carbidopa
- Increased CNS depressant effects when used with MAO inhibitors
Contraindications
Baclofen is contraindicated in patients with hypersensitivity to any component of this product.
Side Effects
- Transient drowsiness
- Daytime sedation
- Dizziness
- Weakness
- Fatigue
- Various central nervous system effects
- Cardiovascular effects
- Gastrointestinal effects
- Genitourinary effects
- Other effects including rash, pruritus, visual disturbances, and hepatic function disorders
Pregnancy & Lactation
Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen is excreted in breast milk however evidence suggests that the quantities are so small that no undesirable effects on the infant would be expected.
Precautions & Warnings
- Lower doses for patients with impaired renal function or chronic haemodialysis
- Cautious use and monitoring in patients with psychotic disorders, schizophrenia, depressive or manic disorders
- Use under appropriate supervision in patients with epilepsy and muscle spasticity
- Caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
- Careful monitoring of respiratory and cardiovascular function, especially in patients with cardiopulmonary disease and respiratory muscle weakness
- Caution in patients with preexisting sphincter hypertonia
Overdose Effects
Gastric lavage is important in case of severe overdose.
Therapeutic Class
Centrally acting Skeletal Muscle Relaxants
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.