Flexibac 5 mg (Tablet)

Unit Price: ৳ 5.50 (5 x 15: ৳ 412.50)
Strip Price: ৳ 82.50

Medicine Details

Category Details
Generic Baclofen
Company Beacon pharmaceuticals plc
Also available as
Flexibac 10 mg tablet Flexibac 25 mg tablet Flexibac 5 mg oral solution

Indications

  • spasticity resulting from multiple sclerosis
  • flexor spasms and concomitant pain
  • skeletal muscle spasm resulting from rheumatic disorders
  • spinal cord injuries
  • cerebrovascular accidents or neoplastic or degenerative brain disease

Pharmacology

Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA B receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.

Dosage & Administration

  • Adult & children over 10 years: 5 mg 3 times daily
  • Children <10 years: 2.5 mg 4 times daily
  • Max. dosage: 100 mg daily

Interaction

  • Increased sedation may occur if taken with agents acting on the central nervous system
  • Combined treatment with antihypertensives is likely to increase the fall in blood pressure
  • Concomitant administration with tricyclic antidepressants may potentiate the pharmacological effects
  • Caution when administering with magnesium sulphate or other neuromuscular blocking agents

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

Side Effects

  • Transient drowsiness
  • Daytime sedation
  • Dizziness
  • Weakness
  • Fatigue
  • Headache
  • Insomnia
  • Euphoria
  • Nausea
  • Constipation
  • Urinary frequency
  • Rash
  • Hepatic function disorders

Pregnancy & Lactation

Baclofen should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards.

Precautions & Warnings

  • Lower doses for patients with impaired renal function
  • Exacerbations of psychotic disorders may occur
  • Seizures have been reported after the cessation of therapy or with overdose
  • Use with caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
  • Careful monitoring of respiratory and cardiovascular function is essential

Overdose Effects

Gastric lavage is important in case of severe overdose.

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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