Liorel 5 mg (Tablet)
Unit Price: ৳ 4.53 (5 x 10: ৳ 226.50)
Strip Price: ৳ 45.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Aci limited |
| Also available as |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
- inhibits monosynaptic and polysynaptic reflexes
- stimulates GABA receptors
- inhibits release of glutamate and aspartate
- produces CNS depression
- exerts antinociceptive effect
Dosage & Administration
- 5 mg 3 times daily for adults & children over 10 years
- gradually increased dosage
- max. 100 mg daily
- treatment for children under 10 years based on age
- daily maintenance dose based on age
Interaction
- increased sedation with CNS acting agents, alcohol, or synthetic opiates
- enhanced fall in blood pressure with antihypertensives
- potentiation of effects with tricyclic antidepressants
- reported effects with concomitant use of levodopa and carbidopa, MAO inhibitors, and magnesium sulphate
Contraindications
- hypersensitivity to any component of the product
Side Effects
- transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- various central nervous system effects
- hypotension
- gastrointestinal effects
- genitourinary effects
- other rare adverse reactions
Pregnancy & Lactation
- Pregnancy category B3
- use only if benefits outweigh possible hazards
- excretion in breast milk with no expected undesirable effects on infant
Precautions & Warnings
- lower doses for impaired renal function or chronic haemodialysis patients
- caution for patients with psychotic disorders, schizophrenia, depressive or manic disorders
- appropriate supervision for epilepsy patients
- caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
- monitoring of respiratory and cardiovascular function
- caution in patients with sphincter hypertonia or preexisting urinary issues
- poor tolerance in stroke patients
- periodic laboratory tests for hepatic diseases or diabetes mellitus
Overdose Effects
- gastric lavage in case of severe overdose
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Keep below 30°C temperature
- away from light & moisture
- keep out of the reach of children